Joseph R. Stimers, Ph.D.
Phone: (501) 686-8035
Fax: (501) 686-5510
University of Southern California, 1982
My research interests include: 1) the biophysics of excitable membranes especially ion channels and ion transport mechanisms; 2) physiology and pharmacology of cardiac muscle; and 3) the role of Na/K pump isoforms in peripheral nervous tissue. In my laboratory we are currently studying mechanisms that regulate the activity of the Na/K pump in cardiac myocytes using the whole patch clamp technique and fluorescent dyes. These studies are clinically relevant to congestive heart failure, hypertrophy and aging. We are also investigating the mechanism of action of phospholipid metabolites on ion channels in the heart which is relevant to a variety of inflammatory and ischemic processes. We have also recently begun using dorsal root ganglion neurons as a model system for studying Na/K pump junction and the role of its isoform. These studies are relevant to diabetic neuropathy and peripheral hyperalgesia.
Recent Research Support
NIH R01HL095846 (CoI) (01/01/2010 – 11/20/13)
MicroRNA to Decrease Vascular CaV1.2 in Hypertension
Stimers JR, Song L, Rusch NJ, Rhee SW. Overexpression of the Large-Conductance, Ca2+-Activated K+ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes. PLoS One. 10(6):e0130588, 2015 (PMID: 26091273).
Thakali KM, Kharade SV, Sonkusare SK, Rhee SW, Stimers JR, Rusch NJ. Intracellular Ca2+ silences L-type Ca2+ channels in mesenteric veins: mechanism of venous smooth muscle resistance to calcium channel blockers. Circ Res. 106(4):739-47, 2010 (PMID: 20044515).
Romanovsky D, Wang J, Al-Chaer ED, Stimers JR, Dobretsov M. Comparison of metabolic and neuropathy profiles of rats with streptozotocin-induced overt and moderate insulinopenia. Neuroscience. 170(1):337-47, 2010 (PMID: 20600635).
Dobretsov M, Stimers JR. Muscle spindle afferents and the mystery of the α3 isoform of Na+,K+-ATPase. J Physiol. 588(Pt 21):4061, 2010 (PMID: 21037311).
Rhee SW, Stimers JR, Wang W, Pang L. Vascular smooth muscle-specific knockdown of the noncardiac form of the L-type calcium channel by microRNA-based short hairpin RNA as a potential antihypertensive therapy. J Pharmacol Exp Ther. 329(2):775-82, 2009 (PMID: 19244098).