Lee Ann MacMillan-Crow, Ph.D.
Professor and Interdisciplinary Toxicology Program Director
Phone: (501) 686-5289
Fax: (501) 686-8970
Ph.D. – University of Alabama at Birmingham, 1994
My laboratory has been funded by the NIH since 2001 and has a long-term interest in oxidant generation and mitochondrial damage during renal ischemia/reperfusion, as it relates to transplantation injury. The laboratory is currently focusing on elucidation of specific pathways involved with mitochondrial dynamics that are altered during renal cold storage. In addition, we are examining the therapeutic potential of several agents to block renal mitochondrial injury during warm and cold ischemia, using rat, porcine, and a human model of transplantation. This research has led to a Use Patent and Phase I Small Business Grant from NIH. Another recent area of study in collaboration with Dr. Philip Mayeux’s laboratory, is currently supported by an NIH RO1 grant is related to the role that mitochondrial superoxide has on mitochondrial and renal damage during sepsis. Finally, a new project in collaboration with Dr. Nancy Rusch’s laboratory, is exploring the role of a novel mitochondrial large conductance potassium channel has in mitochondrial damage during renal cold storage.
Recent Research Support
R01 GM106419 NIH/NIGMS (MPI) (02/01/14 – 01/31/18)
“Mitochondrial Injury and Repair in Sepsis-induced Acute Kidney Injury”
P20 GM109005 NIH/NIGMS (Mentor of Project I) (07/01/15 – 06/31/18)
“Center for Studies of Host Response to Cancer Therapy”
16PRE30830010 American Heart (Mentor) (07/1/16 – 06/30/18)
“Role of mitoBK channels in renal cold preservation”
RO1 DK078936 NIH/NIDDK (PI) (12/1/08 – 11/30/15) (extension)
“Manganese Superoxide Dismutase and Renal Ischemia/Reperfusion”
UL1TR000039 NIH (PI) (10/01/14 – 09/31/15)
“Novel Therapy to Reduce Injury to Human Donor Kidneys Prior to Transplant”
Srivastava AK, MacMillan-Crow LA, Rhee SW, Rusch NJ (2016). Abnormalities of vascular ion channels during hypertension. In: Vascular Ion Channels in Physiology and Disease, Levitan I and Dopico A (eds), Spring International Publishing AG, New York, NY (in press).
Singh, P, Parajuli, N, Mayeux PR, MacMillan-Crow LA. Renal Mitochondrial Lipid Peroxidation during Sepsis. Journal of Kidney. Feb;2(1),116, 2016 (PMID: 27104220).
Shrum S, MacMillan-Crow LA, and Parajuli N. Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. Journal of Kidney. Feb;2(1),114, 2016 PMID: 27066594).
Marine A, Krager, KJ, Aykin-Burns N, MacMillan-Crow LA. Peroxynitrite Induced Mitochondrial Biogenesis Following MnSOD Knockdown in Normal Rat Kidney (NRK) Cells, Redox Biology. 2: 348–357, 2014 (PMID: 24563852).
Patil N, Parajuli N, MacMillan-Crow LA, Mayeux PR. Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. American Journal of Physiology. Renal Physiology. 306, 2014 (PMID: 24500690). *LAMC corresponding author.
Parajuli N, Campbell LH, Marine A, Brockbank KG, MacMillan-Crow LA. Mito Q blunts Mitochondrial and Renal Damage during Cold Preservation of Porcine Kidneys. PLOS One. 7:11, 2012 (PMID: 23139796).
Parajuli N, MacMillan-Crow LA. Role of reduced manganese superoxide dismutase in ischemia/reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis? American Journal of Physiology. Renal Physiology. 304(3):F257-67, 2012 (PMID: 24563852).
Nirmala Parajuli, Akira Marine, Sloane Simmons, Hamida Saba, Tanecia Mitchell, Takahiko Shimizu, Takuji Shirasawa and Lee Ann MacMillan-Crow. Generation and characterization of novel kidney-specific manganese superoxide dismutase knockout mouse. Free Radical Biology and Medicine. 51(2):406-16, 2011 (PMID: 21571061).