MacMillan-Crow Laboratory

Research Team

macmillan-crow-group

macmillan-crow-1Lee Ann MacMillan-Crow, Ph.D. (Principal Investigator)

Dr. MacMillan-Crow received her PhD (Pharmacology/Toxicology) from the University of Alabama at Birmingham in 1994 and moved to UAMS in 2003. She has served as primary mentor to 10 graduate students and served on 18 dissertation committees.

 

 

MacMillan Crow and ParajuliNirmala Parajuli, Ph.D. (Co-Investigator)

Dr. Parajuli joined Dr. MacMillan-Crow’s lab in 2009 as a postdoctoral fellow to research the clinically important topic related to mitochondrial oxidants and renal ischemia/reperfusion injury. During her post-doctoral training, she set up the high resolution respirometry (HRR) method in her mentor’s lab, which is useful for real-time assessment of mitochondrial function using fresh renal biopsies. She also has received very specialized microsurgical training on renal transplant using a rodent model (mouse and rat) from the UAB-UCSD O’Brien Core Center for Acute Kidney Injury. Currently, she is pursuing her own independent research project on proteasome mediated mitochondrial and renal damage. As a collaborator, she is helping Dr. MacMillan-Crow to investigate the molecular mechanisms of kidney injury pre- and post-transplant. One of her projects investigates the mechanisms that disrupt mitochondrial dynamics during renal cold storage and transplantation. Our hypothesis is that increased mitochondrial fragmentation leads to renal damage during renal cold storage and transplantation. The other project studies the role of MitoBK channels on mitochondrial/renal function during renal cold storage and transplantation. Her specialized skill sets will be fundamental to both of these projects of Dr. MacMillan-Crow.

stephen-shrumStephen Shrum, B.S. (Ph.D. Candidate)

Stephen Shrum received his B.S. in Biochemistry & Molecular Biology from Hendrix College May 2014. He is a third year graduate student in the Interdisciplinary Biomedical Sciences program and is under the co-mentorship of Dr. MacMillan-Crow and Dr. Rusch since June 2015. He is currently researching on the role of the mitochondrial BK channel in renal cold storage injury. Stephen is a former trainee in the Systems Pharmacology and Toxicology T32 (SPaT) Training Program.

 

Julia Tobacyk, B.S. (Ph.D. Candidate)

Julia Tobacyk received her B.S. in Biological Science and Chemistry from Louisiana Tech University May 2014. She is a third year graduate student in the Pharmacology prgram and is mentored by Dr. MacMillan-Crow and Dr. Parajuli. Julia is a trainee in the Systems Pharmacology and Toxicology T32 (SPaT) Training Program.

 

alex-harbAlex Harb (Research Technician)

 

 

 

 

Past Graduates

Naeem's DefenseNaeem Patil, Ph.D.

Naeem Patil, a recent graduate, was mentored by Dr. Mayeux and Dr. MacMillan-Crow. His research was funded by an AHA Predoctoral Fellowship to study the role of superoxide and Mn-superoxide dismutase in sepsis-induced renal injury.

 

 

mentor awardTanecia Mitchell, Ph.D.

Tanecia Mitchell, shown with Dr. MacMillan-Crow, received her Ph.D. in 2011 and is now a postdoctoral fellow at UA Birmingham in the laboratory of Dr. Victor Darley-Usmar. She is a trainee on the Institutional Training grant focused on kidney related research.

 

 

 

akiraAkira Marine, J.D., Ph.D.

Dr. Marine is a graduate of the Interdisciplinary Toxicology Program. She received her Ph.D. in March 2014 after successfully defending her research project “Mitochondrial Biogenesis following Maganese Superoxide Dismutase Knockdown.”