UAMS.EDU

Nirmala Parajuli, Ph.D.

ParajuliInstructor
Phone: (501) 686-5290
Fax: (501) 686-8970
Email: Nparajuli@uams.edu

Education

DVM, Tribhuvan University, Nepal, 2001
MVSc, Seoul National University, S. Korea, 2005
Ph.D. Innsbruck Medical University, Austria, 2009

Research Interests

I am interested in unveiling the precise molecular mechanisms responsible for cold storage (CS)-induced renal damage. My research focuses on exploring novel mechanisms by which CS damages mitochondria and importantly, to identify a possible therapeutic target that could lead to improved mitochondrial function before and after transplantation. Specifically, I plan to investigate the role of proteasome in mediating mitochondrial damage and renal dysfunction after CS and transplantation. We have established a syngeneic rat kidney transplantation model in Dr. MacMillan-Crow’s laboratory(my post-doctoral mentor), which will be fundamental in studying my independent research project on proteasome mediated mitochondrial and renal damage. In addition, I’m also collaborating with Dr. MacMillan-Crow to study the molecular mechanisms that disrupt mitochondrial dynamics during renal CS and transplantation using our rat kidney transplant model.

Meet Dr. Parajuli’s Research Team

Recent Research Support

Current Research
163DG27600026  American Heart  (PI)  (07/01/16 – 06/30/19)
“Ubiquitin Proteasome System, Mitochondria and Renal Cold Storage”

Completed Research
5T32D61921   (Post-Doctoral Researcher)  (07/01/13 – 06/01/16)
“Proteasome, mitochondira and CS/transplantation”

Publications

Shrum S, MacMillan-Crow LA, Parajuli, N. Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. Journal of Kidney. 2(1), 2016 (PMID: 27066594).

Singh P, Parajuli, N, Mayeux PR, MacMillan-Crow LA. Renal mitochondrial lipid peroxidation during sepsis. Journal of Kidney. 2(1), 2016 (PMID: 27104220).

Patil N, Parajuli N, Mayeux PR, MacMillan-Crow LA. Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury even with delayed therapy. Am J Phsiol Renal Physiol. 306(7):F734-43, 2014 (PMID: 24500690).

Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W. Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1. Journal of Leukocyte Biology. J Leukoc Biol. 95(6):853-66, 2014 (PMID: 24295829).

Hannesdóttir L, Tymoszuk P, Parajuli N, Wasmer MH, Philipp S, Daschil N, Datta S, Koller JB, Tripp CH, Stoitzner P, Müller-Holzner E, Wiegers GJ, Sexl V, Villunger A, Doppler W. Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur J Immunol. 43(10):2718-29, 2013 (PMID: 23843024).

Marecki JC, Parajuli N, Crow JP, Macmillan-Crow LA. The Use of the Cre/loxP System to Study Oxidative Stress in Tissue-Specific Manganese Superoxide Dismutase Knockout Models. Antioxid Redox Signal. 20(10):1655-70, 2013 (PMID: 23843024).

Parajuli N and MacMillan-Crow LA. Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis? Am J Physiol Renal Physiol. 304(3):F257-67, 2013 (PMID: 23195678).

Parajuli N, Campbell LH, Marine A, Brockbank KG, Macmillan-Crow LA. MitoQ blunts mitochondrial and renal damage during cold preservation of porcine kidneys. PLoS One. 7(11): e48590, 2012 (PMID: 23139796).

Parajuli N, Marine A, Simmons S, Saba H, Mitchell T, Shimizu T, Shirasawa T, Macmillan-Crow LA. Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse. Free Radic Biol Med. 15;51(2):406-16, 2011 (PMID: 21571061).

Mitchell T, Saba H, Laakman J, Parajuli N, MacMillan-Crow LA. Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury. Free Radic Biol Med. 1;49(8):1273-82, 2010 (PMID: 20659553).

View Dr. Parajuli’s Publication List