Dr. Prather’s research involves understanding the neurobiological mechanisms underlying the addictive states produced by drugs of abuse. Specifically, he investigates the cellular and molecular mechanisms of signal transduction mediated by G-protein coupled receptors (GPCRs) with which drugs of abuse interact. He has recently shown that active phase I hydroxylated metabolites of synthetic cannabinoids present in K2/Spcie may contribute to the rather unique toxicity profile associated with use of these drugs. As such, his laboratory provides students with the opportunity to employ cellular and molecular techniques to characterize the pharmacological and toxicological properties of novel drugs of abuse.
Max is a Ph.D. Candidate whose research interest is in vitro and in vivo investigation of biased ligands at CB1 and CB2 receptors.
Christian is a graduate student whose current research interest is in signal transduction.