Dr. Philip R. Mayeux (Principal Investigator)
Dr. Mayeux has been studying acute kidney injury for many years. His current efforts are focused on understanding the causes of kidney injury resulting from sepsis, both in the elderly and pediatric population. His interest is developing and testing the therapeutic potential of new drugs in rodent models of sepsis.
Lascelles Lyn-Cook is a fourth year student working in Dr. Mayeux’s lab, under the co-mentorship of Dr. Alison Harrill and Dr. Mayeux.
The Diversity Outbred (DO) mice comprise a genetically diverse population with genetic variability that is actually greater than the human population. We hypothesized that the DO mice, when used in preclinical drug screening, would accurately predict human relevant liver toxicities that conventional models missed. We have selected one drug – zileuton – for mechanistic assessment. We performed pathological analysis and immunohistochemistry in the liver of sensitive and resistant DO mice to ascertain molecular changes that occur in susceptible individuals. Supported by T32 GM106999 (2014-2016). Supported by SREB Doctoral Scholars Program (2016-2017).
Past Mayeux Research Team
From left, Philip Mayeux, Ph.D., J. Hunter Holthoff Ph.D., Elina Pathak, Ph.D., Zheng Wang, Ph.D., and Naeem Patil, Ph.D.
J. Hunter Holthoff received his Ph.D. in 2012. He has completed his M.D. degree and is currently a resident in Internal Medicine at UAMS.
Dr. Elina Pathak graduated with her Ph.D. in 2012 and is currently in a postdoctoral fellowship under Dr. Bing Lim at the Genome Institute of Singapore.
Dr. Zheng Wang graduated with his Ph.D. in 2012 and is currently working in a post-doc position in Dr. John Hall’s lab at the University of Mississippi Medical Center.
Dr. Naeem Patil graduated with his Ph.D. in 2014 and has accepted a post-doc position in the lab of Dr. Edward Sherwood at Vanderbilt University.