Journal Club

Fall 2016 Schedule

Student Journal Club presentations are held at noon in Biomed I, Room B300.

September 8, 2016 – Organizational Meeting

September 15, 2016 – Chuck Hay (Peterson Laboratory)

Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, Bandi SR, Calabrese CR, Walle LV, Lamkanfi M, Kanneganti TD. Dietary modulation of the microbiome affects autoinflammatory disease.  Nature. 2014; 516(11): 246-260.

Summary: This cool paper suggests that a person’s diet may impact downstream whether their innate immune system develops a taste for bones (autoimmune osteomyelitis. Read this paper and come to this week’s journal club to find out more.

September 22, 2016 – TBA

September 29, 2016 – TBA

October 6, 2016 – UAMS Career Day

October 13, 2016 – Lauren Russell (Fantegrossi Lab)

Anneken JH, Angoa-Perez M, Kuhn DM. 3,4-Methylenedioxypyrovalerone prevents while methylone enhances methamphetamine-induced damage to dopamine nerve endings: β-ketoamphetamine modulation of neurotoxicity by the dopamine transporter.  Journal of Neurochemistry. 2015; 133: 211-222.

October 20, 2016 – Speaker Rescheduled

October 27, 2016 – Brittney Garner (Rusch Lab)

Le CP, Nowell CJ, Kim-Fuchs C, Botteri E, Hiller JG, Ismail H, Pimentel MA, Chai MG, Karnezis T, Rotmensz N, Renne G, Gandini S, Pouton CW, Ferrari D, Moller A, Stacker SA, Sloan EK. Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination.  Nature Communications.  2016; 7: 10634.

November 2, 2016 – Catheryn Wilson (Prather Lab)

Grim TW, Morales AJ, Gonek MM, Wiley JL, Thomas BF, Endres GW, Sim-Selley LJ, Selley DE, Negus SS, Lichtman AH. Stratification of cannabinoid 1 receptor (CB1R) agonist efficacy: Manipulation of CB1R density through use of transgenic mice reveals congruence between in vivo and in vitro assays. JPET. 2016; Epub ahead of print.

November 9, 2016 – Stephen Shrum (MacMillan-Crow/Rusch Lab)

Bednarczyk P, Wieckowski MR, Broszkiewicz M, Skowronek K, Siemen D, Sqewczyk A. Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain. PLoS ONE. 2013;8(6):e68125.

November 16, 2016 – Michael Cozart (Zheng Lab)

Kohara K, Pignatelli M, Rivest AJ, Jung H-Y, Kitamura T, Suh J, Frank D, Kajikawa K, Mise N, Obata Y, Wickersham IR, Tonegawa S.   Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits.  Nature Neuroscience.  2013; 17(2): 269-279.

November 24, 2016 – Thanksgiving Holiday

November 30, 2016 – Samantha McClenahan (Owens Lab)

Haiser HJ, Gootenberg DB, Chatman K, Sirasani G, Balskus EP, Turnbaugh PJ.  Predicting and manipulating cardiac drug inactivation by the human gut bacterium eggerthella lenta. Science. 2013; 341: 295-298.

December 7, 2016 – Julia Tobacyk (Koturbash Lab)

Strekalova E, Malin D, Good DM, Cryns VL. Methionine deprivation induces a targetable vulnerability in triple-negative breast cancer cells by enhancing TRAIL receptor-2 expression.   Clin Cancer Res. 2015; 21(12): 2780-2791.

Summary:   This study shows that in the absence of methionine, cancer cells undergo cell cycle arrest followed by cell death and potentiates the efficacy of chemotherapy agents.

December 14, 2016 – Bill Hyatt (Fantegrossi Lab)

Marusich JA, Lefever TW, Blough BE, Thomas BF, Wiley JL. Examination of vaporization of methamphetamine and alpha-PVP using e-cigarette-like devices in vivo reveals stimulant-like effects comparable to toxicological and pharmacological profiles following IP injections. NeuroToxicology. 2016; 55: 83-91.

Spring 2017 Schedule

January 18, 2017 – Brittney Garner (Rusch Lab)

Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans. Hypertension. 2016 Jul;68(1):123-32. doi: 10.1161/HYPERTENSIONAHA.116.07237. Epub 2016 May 23.

February 1, 2017 – Seager-Braswell Symposium

February 8, 2017 – Samantha McClenahan (Owens Lab)

Heart rates of male and female Sprague-Dawley and spontaneously hypertensive rats housed singly or in groups. J Am Assoc Lab Anim Sci. 2011 Mar;50(2):175-84.

February 15, 2017 – Lauren Russell (Fantegrossi Lab)

Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol. Addict Biol. 2016 Apr 28. doi: 10.1111/adb.12405.

February 22, 2017 – Michael Cozart (Zheng Lab)

Unveiling astrocytic control of cerebral blood flow with optogenetics. Sci Rep. 2015 Jun 16;5:11455. doi: 10.1038/srep11455.

March 1, 2017 – William Hyatt (Fantegrossi Lab)

Cocaine administration dose-dependently increases sexual desire and decreases condom use likelihood: The role of delay and probability discounting in connecting cocaine with HIV. Psychopharmacology (Berl). 2016 Dec 5

March 8, 2017 – Charles Hay (Peterson Lab)

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice. MAbs. 2016;8(1):120-8. doi: 10.1080/19420862.2015.1113360.

March 15, 2017 – Catheryn Wilson (Fantegrossi Lab)

Free and Glucuronide Whole Blood Cannabinoids’ Pharmacokinetics after Controlled Smoked, Vaporized, and Oral Cannabis Administration in Frequent and Occasional Cannabis Users: Identification of Recent Cannabis Intake.Clin Chem. 2016 Dec;62(12):1579-1592. Epub 2016 Oct 10.

March 22, 2017 – Spring Break

March 29, 2017 – Chris Bolden (Peterson Lab)

Peripheral ammonia and blood brain barrier structure and function after methamphetamine. Neuropharmacology. 2016 Aug;107:18-26.

April 5, 2017 – Ryan Macleod (O’Brien Lab)

The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human β-thalassemia in Mice. Scientific Reports. 2016 Sept; 6:32463

April 12, 2017 – Research Day

April 19, 2017 – Julia Tobacyk (Koturbash Lab)

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35. doi: 10.1152/ajpheart.00235.2008. Epub 2008 Apr 18.

April 26, 2017 – Experimental Biology Meeting

May 3, 2017 – Dolapo Adejumobi (Kurten Lab)

LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium. Mucosal Immunol. 2016 May;9(3):744-56. doi: 10.1038/mi.2015.98. Epub 2015 Oct 14

May 10, 2017 – Stephen Shrum (MacMillan-Crow Lab)

Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive RatsNovelty and Significance. Hypertension.