Meet Our Students
Research Interests: Determining the functions of canonical transient receptor potential channel 3 (TRPC3) in neurovascular coupling and stroke-induced neural damage. TRPC3 is a cation channel known to regulate intracellular calcium in neurons, astrocytes, vascular smooth muscle cells (VSMCs), and cerebral endothelial cells – all the principal members of the neurovascular unit. Blockage of TRPC3 has recently been shown to be neuroprotective in a hemorrhagic model of stroke. However, the role of TRPC3 remains unclear as other studies have shown that loss of TRPC3 function is associated with a loss of endothelium-dependent dilation of cerebral arteries, which should in theory lead to an increase in stroke-induced damage. Answering these questions may lead to a pharmacological target for stroke therapy.
Research Interests: In vitro and in vivo investigation of biased ligands at CB1 and CB2 receptors.
Research Interests: Autoimmunity, pathogenesis, biologic drug development especially monoclonal antibodies as drugs, and drugs of abuse.
Research Interests: The role of diet in cancer therapy.
Research Interests: Utilizing viral expressed scFvs to reduce Methamphetamine’s neuroinflammatory effects.
Lascelles Lyn-Cook, M.S.
Co-Mentors: Alison Harrill, Ph.D. and Philip Mayeux, Ph.D.
Undergraduate Degree: University of Arkansas at Little Rock
Masters Degree: University of Arkansas for Medical Sciences
Research Interests: Diversity outbred mice may improve preclinical screening for drug-induced liver injury (DILI).
Research Interests: Effects of synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinovalerophenone (α-PVP) on impulsivity and vulnerability to psychostimulant abuse.
Co-Mentors: Lee Ann MacMillan-Crow, Ph.D. and Nancy Rusch, Ph.D.
Undergraduate Degree: Hendrix College
Research Interests: The role of the mitochondrial BK channel in renal cold storage injury.
Research Interests: Ion channel remodeling in lymphedema.
Research Interests: Exploring the effects of toxins and drugs at the whole-animal level.
Research Interests: Studying the effects of synthetic cannabinoids using in vivo and in vitro approaches.
Research Interests: Neuro degeneration
Research Interests: Signal transduction.
Research Interests: Interactions of diet and radiotherapy in improving cancer treatment outcomes.
Research Interests: The effects of drugs of abuse on behavior and the biological mechanisms responsible for producing these effects. He is specifically focusing his training on the behavioral pharmacology of synthetic opiods.