Spring 2018-2019 Schedule

January 9, 2019 – Samantha McClenahan & Laura Ewing

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13030

Bosnano JS, Banks ML, Kolanos R, Sakloth F, Barnier ML, Glennon RA, Cozzi NV, Partilla JS, Baumann MH, Negus SS.  Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues. British Journal of Pharmacology. 2015, May; 172(10):2433-2444. PMID: 25438806.

January 16, 2019 – David Henry & Lauren Russell

http://stm.sciencemag.org/content/10/426/eaan4488.short

Sagiv-Barfi I, Czerwinkski DK, Levy S, Alam IS, Mayer AT, Gambhir SS, Levy R. Eradication of spontaneous malignancy by local immunotherapy. Science Translational Medicine. 2018, Jan 31; 10(426): eaan4488. PMID: 29386357

January 23, 2019 – Cancelled

January 30, 2019 – Julia Tobacyk & Amal Shoeib

https://www.nature.com/articles/s41598-017-13282-7

Carhart-Harris RL, Roseman L, Bolstridge M, Demetriou L, Pannekoek JN, Wall MB, Tanner M, Kaelen M, McGonigle J, Murphy K, Leech R, Curran HV, Nutt DJ.  Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Sci Rep. 2017, Oct 13; 7(1): 13187. PMID: 29030624

February 6, 2019 – Cancelled

February 13, 2019 – Kyle Urquhart & Julia Tobacyk

http://molpharm.aspetjournals.org/content/88/2/335.long

Thompson GL, Lane JR, Coudrat T, Sexton PM, Christopoulos A, Canals M.  Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor. Mol Pharmacol. 2015 Aug; 88(2): 335-46. PMID: 2601354

February 20, 2019 – Brittney Garner & David Henry

https://www.sciencedirect.com/science/article/pii/S2211124718315031?via%3Dihub

Chakraborty S, Galla S, Cheng X, Yeo J-Y, Mell B, Singh V, Yeoh B, Saha P, Mathew AV, Vijay-Kumar M, Joe B. Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension. Cell Rep. 2018 Oct 16;25(3):677-689.e4. PMID: 30332647

February 27, 2019 – Christian Cabanlong & Brittney Garner

http://molpharm.aspetjournals.org/content/88/2/368.long

Khajehali E, Malone DT, Glass M, Sexton PM, Christopoulos A, Leach K. Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor. Mol Pharmacol. 2015 Aug; 88(2): 368-379. PMID: 26044547

March 6, 2019 – Stephen Shrum & Kyle Urquhart

https://onlinelibrary.wiley.com/doi/full/10.1111/adb.12639

Hemby SE, McIntosh S, Leon F, Cutler SJ, McCurdy CR.  Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.  Addict Biol. 2018 Jun 27. doi: 10.1111/adb.12639. PMID: 29949228

March 13, 2019 – Cancelled

March 20, 2019 – Spring Break

March 27, 2019 – Allie Davis & Stephen Shrum

https://www.nature.com/articles/nature18928

Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Changhong X, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 Jul 28; 535(7613):551-555. PMID: 27466127

April 3, 2019 – Laura Ewing & Allie Davis

https://www.pnas.org/content/112/51/E7138.long

Wheeler DS, Underhill SM, Stolz DB, Murdoch GH, Thiels E, Romero G, Amara SG. Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine.  Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51): E7138-47. PMID: 26553986

April 17, 2019 – Melissa Clemens & Christian Cabanlong

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191299

Barry RL, Byun NE, Williams JM, Siuta MA, Tantawy MN, Speed NK, Saunders C, Galli A, Niswender KD, Avison MJ. Brief exposure to obesogenic diet disrupts brain dopamine networks.  PLoS One. 2018 Apr 26;13(4):e0191299. PMID: 29698491

April 24, 2019 – Amal Shoeib & Melissa Clemens

https://www.pnas.org/content/115/50/12616.long

Milojevic S, Radicchi F, Walsh JP. Changing demographics of scientific careers: the rise of the temporary workforce. PNAS.  2018, Dec 11; 115(50): 12616-12623. PMID: 3053069

Fall 2018-2019 Schedule

September 5, 2018 – Julia Tobacyk & Samantha McClenahan

Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PC, Strassman RJ. Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol. 2015 Mar;29(3):289-99. doi: 10.1177/0269881114565144. Epub 2015 Jan 13. PMID: 25586396

September 12, 2018 – Chris Bolden & Lauren Russell

http://jpet.aspetjournals.org/content/344/3/708.long

DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17. doi: 10.1124/jpet.112.201616. Epub 2013 Jan 8. PMID: 23300227

September 19, 2018 – Christian Cabanlong & David Henry

https://www.sciencedirect.com/science/article/pii/S0140673612620893?via%3Dihub

Moodie R, Stuckler D, Monteiro C, Sheron N, Neal B, Thamarangsi T, Lincoln P, Casswell S; Lancet NCD Action Group.  Profits and pandemics: prevention of harmful effects of tobacco, alcohol, and ultra-processed food and drink industries.  Lancet. 2013 Feb 23;381(9867):670-9. doi: 10.1016/S0140-6736(12)62089-3. Epub 2013 Feb 12. PMID: 23410611

September 26, 2018 – Melissa Clemens & Samantha McClenahan

Simmler LD, Buser TA, Donzelli M, Schramm Y, Dieu LH, Huwyler J, Chaboz S, Hoener MC, Liechti ME. Pharmacological characterization of designer cathinones in vitro. Br J Pharmacol. 2013 Jan;168(2):458-70. doi: 10.1111/j.1476-5381.2012.02145.x. PMID: 22897747

October 3, 2018 – Lauren Russell & Julia Tobacyk

Jiang M, Wei Q, Dong G, Komatsu M, Su Y, Dong Z. Autophagy in proximal tubules protects against acute kidney injury. Kidney Int. 2012 Dec;82(12):1271-83. doi: 10.1038/ki.2012.261. Epub 2012 Aug 1. PMID: 22854643

October 10, 2018 – Stephen Shrum & Kyle Urquhart

Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, Fujimoto S, Terada Y.  Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F495-509. doi: 10.1152/ajprenal.00642.2012. Epub 2013 May 22. PMID: 2368117

October 18, 2018 – Kyle Urquhart & Chris Bolden

Morales AI, Detaille D, Prieto M, Puente A, Briones E, Arévalo M, Leverve X, López-Novoa JM, El-Mir MY. Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway. Kidney Int. 2010 May;77(10):861-9. doi: 10.1038/ki.2010.11. Epub 2010 Feb 17. PMID: 20164825

October 24, 2018 – Brittney Garner & Catheryn Wilson

https://www.sciencedirect.com/science/article/pii/S0085253815558353?via%3Dihub

Sorensen MV, Grossmann S, Roesinger M, Gresko N, Todkar AP, Barmettler G, Ziegler U, Odermatt A, Loffing-Cueni D, Loffing J. Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice.  Kidney Int. 2013 May;83(5):811-24. doi: 10.1038/ki.2013.14. Epub 2013 Feb 27. PMID: 23447069

October 31, 2018 – Melissa Clemens & Laura Ewing

De Miguel C, Guo C, Lund H, Feng D, Mattson DL. Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease. Am J Physiol Renal Physiol. 2011 Mar;300(3):F734-42. doi: 10.1152/ajprenal.00454.2010. Epub 2010 Dec 15. PMID: 21159736

November 7, 2018 – Catheryn Wilson & Stephen Shrum

Nikolaev VO1, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J.  Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 2010 Mar 26;327(5973):1653-7. doi: 10.1126/science.1185988. Epub 2010 Feb 25. PMID: 20185685

November 14, 2018 – David Henry & Brittney Garner

Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther. 2012 Apr;341(1):274-84. doi: 10.1124/jpet.111.190132. Epub 2012 Jan 20. PMID: 22267202

November 28, 2018 – Laura Ewing & Christian Cabanlong

McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M, Dong X. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015 Mar 12;519(7542):237-41. doi: 10.1038/nature14022. Epub 2014 Dec 17. PMID: 25517090