Fang Zheng, Ph.D.

Fang ZhengAssociate Professor
Phone: 501-686-7632
Fax: 501-686-5521


Ph.D. – University of Texas Medical Branch at Galveston, 1994

Research Interests

My laboratory studies the regulation of glutamate receptors, an important family of neurotransmitter receptors. Glutamate receptors are involved in multiple neurological diseases, such as stroke-induced paralysis and cognitive dysfunction, epilepsy, and perhaps the debilitating consequences of Alzheimer’s disease, the neurological correlates of schizophrenia and ALS. By better understanding these receptors, we will better understand the underlying causes of these diseases, and be better equipped to develop effective treatments for these serious conditions. My laboratory utilizes a multidisciplinary approach that utilizes molecular, biochemical, and electrophysiological techniques.

View Dr. Zheng’s Research

Recent Research Support

Completed Research
NIH/NINDS R01 NS039418 (05/01/00 – 4/30/11)
“Zinc dependent apparent desensitization of NMDA receptors”

NIH/NINDS R01 NS058503 (07/01/09 – 6/30/11)
“Canonical transient receptor potential channels and excitotoxicity”


Phelan KD, Shwe UT, Cozart MA, Wu H, Mock MM, Abramowitz J, Birnbaumer L, Zheng F. TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice. Epilepsia.  58(2):247-254, 2017. PMID: 28012173

Zheng F. TRPC Channels and Epilepsy. Adv Exp Med Biol. 976:123-135, 2017. PMID: 28508318

Phelan KD, Shwe UT, Williams DK, Greenfield LJ, Zheng F. Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. Epilepsy Res. 117:90-6, 2015. PMID: 26432759

Phelan KD, Shwe UT, Abramowitz J, Birnbaumer L, Zheng F. Critical role of canonical transient receptor potential channel 7 in initiation of seizures. Proc Natl Acad Sci U S A. 5;111(31):11533-8, 2014. PMID: 25049394

Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F. Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms. Mol. Pharmacol. 83, 429-438, 2013. PMID: 23188715

Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A, Birnbaumer L, Freichel M, Flockerzi V,  Zheng F.  Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol. Pharmacol. 81, 384-392, 2012. PMID:  22144671

View Dr. Zheng’s Publication List