Shengyu Mu, M.D., Ph.D.

Shengyu Mu, M.D., Ph.D.Assistant Professor
Phone: (501) 603-1081
Fax: (501) 686-8970
SMu@uams.edu

Education

M.D. – TianJin Medical University, TianJin, China, 2004
Ph.D. – The University of Tokyo, Tokyo, Japan, 2011

Research Interests

The primary interest of my research has been focusing on the pathogenesis of hypertension in renal salt-reabsorption and the systemic vasculature. The long-term goal of our laboratory is to understand the mechanism of the development of hypertension and to translate our basic scientific discovery to clinics to contribute to a final cure for hypertension. To accomplish this goal, we have conducted multiple screenings to identify potential pathogenic targets in hypertension. Extending from our initial screen, we are performing laboratory experiments using both pharmacological and genetic approaches to determine the role of the identified molecules in the development of hypertension. Our most recent project is investigating the role and molecular mechanisms of immune cells in stimulating sodium retention in kidney, which contributes to the pathogenesis of salt-sensitive hypertension. In addition, we have acquired techniques and research experience involved in most areas of physiology, biology, molecular genetics, epigenetics, histology and vascular biology that are needed to pursue our goal of translational medicine. I am collaborating with Phil Palade, Ph.D. and Yunmeng Liu, Ph.D. on this research.

Recent Research Support

Current Research

R01, HL146713-01, NIH, NHLBI, (PI) (04/01/2019-03/31/2024)
“T cell homing to the kidney contributes to salt retention and blood pressure regulation”

Completed Research

Medical Research Endowment Awards, UAMS, (PI) (2019-2020)
“Role of renal lymph-angiogenesis in salt-sensitive hypertension”

AWD00052492 Sturgis  (Co-I)  (11/15/17 – 12/31/18)
“Targeting of TRPC3 Channels to Normalize Vascular Tone”

15BGIA25730047  AHA  (PI)  (07/01/15 – 06/30/17)
“Role of Immune Cells in kidney in the Development of Salt-Sensitive Hypertension”

Publications

Ding Z, Wang X, Liu S, Zhou S, Kore R, Mu S, Deng X, Fan Y, Mehta JL, NLRP3 inflammasome via IL-1β regulates PCSK9 secretion. Theranostics.  2020; 10(16): 7100-7110

Dai L, Chen J, Lin Z, Wang Z, Mu S, Qin Z,  Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). Journal of Cancer.  2020; 11(16): 4683-4691.

Cozart MA, Phelan KD, Wu H, Mu S, Birnbaumer L, Rusch NJ, Zheng F. Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus. Sci Rep. 2020; 10(1): 812. PMID: 31964991

Liu S, Deng X, Zhang P, Wang X, Fan Y, Zhou S, Mu S, Mehta JL, Ding Z. Blood flow patterns regulate PCSK9 secretion via MyD88 mediated proinflammatory cytokines. Cardiovasc Res. 2019 Oct 8. pii: cvz262. [Epub ahead of print]. PMID: 31593224

Zheng F, Mu S, Rusch NJ..  Leptin Activates Trpm7 Channels in the Carotid Body As a Mechanism of Obesity-Related Hypertension. Circ Res. 2019; 125(11): 1003-1005. PMID: 31697634

Mu S, Fantegrossi WE, Rusch NJ. Cocaine-Responsive miRNA and Blood Pressure Elevation. Hypertension. 71(4):561-562, 2018. PMID: 29483229

Sims CR, Singh SP, Mu S, Gokden N, Zakaria D, Nguyen TC and Mayeux PR. Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome. Frontiers in Pharmacology. 8: 237; 2017. PMID: 28515693

Liu Y, Rafferty T, Rhee S, Webber J, Song L, Ko B, Hoover R, He B, Mu S. CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension. Nat. Commun. 8, 10437; 2017. PMID: 28067240

Uetake Y, Ikeda H, Irie R, Tejima K, Matsui H, Ogura S, Wang H, Mu S, Hirohama D, Ando K, Sawamura T, Yatomi Y, Fujita T, Shimosawa T. High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice. Lipids Health Dis. 14:6, 2014. PMID: 25888871

Jimbo R, Kawakami-Mori F, Mu S, Hirohama D, Majtan B, Shimizu Y, Yatomi Y, Fukumoto S, Fujita T, Shimosawa T. Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency. Kidney Int. 85(5): 1103-11, 2013. PMID: 24088960

Ogura S, Shimosawa T, Mu S, Sonobe T, Kawakami-Mori F, Wang H, Uetake Y, Yoshida K, Yatomi Y, Shirai M, Fujita T. Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor. Am J Physiol Heart Circ Physiol. 305(2):H155-62, 2013. PMID: 23686713

Mori-Kawakami F, Shimosawa T, Wang H, Ogura S, Mu S, Yatomi Y, Fujita T.    NADPH oxidase-mediated Rac1 GTP activity is necessary for non-genomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus.     Am J Physiol Endoc Metab. 302(4): E425-32, 2012. PMID: 22114025

Shimosawa T, Mu S, Shibata S, Fujita T. The Kidney and Hypertension: Pathogenesis of Salt-Sensitive Hypertension. Curr Hypertens Rep. 14(5): 468-472, 2012. PMID: 22752520

Shibata S*, Mu S*, Kawarazaki H*, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayusawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T. (*equal contributor) Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathwayJ Clin Invest. 121 (8):3233-3243, 2011. PMID: 21765214

Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T.  Epigenetic modulation of the renal b-adrenergic-WNK4 pathway in salt-sensitive hypertension.  Nat Med. 17(5):573–580, 2011. PMID: 21499270

View Dr. Mu’s Publication List