Shuk-Mei Ho, Ph.D.

Professor, Department of Pharmacology and Toxicology
UAMS, Vice Chancellor for Research and Innovation
Phone: 501-686-5347
Fax: (include fax number)
shukmeiho@uams.edu

 Education 

BSc – University of Hong Kong, 1974
Ph.D. –University of Hong Kong, 1978
Postdoc – Boston University, 1980

Recent Research Support

Completed Research Support (selected projects from past three years)

VA BLRD Merit Award (PI) Co-I: Ricky Leung, Neville Tam  (10/01/20 – 09/30/24)
Consultants: Dr. Jun Ying (Department of Biostatistics), Dr. Stephanie Byrum (Department of Biochemistry and Molecular Biology)
Title: Metal-induced cell-level changes in prostate epithelium and cancer risk

VA 5I01BX000675 (PI)  (10/01/2009 – 12/31/2019)
“Estrogen-based combinatorial therapies for castration-resistant prostate cancer”

NIH R01 HL138481 (Collaborator) (08/01/2017 – 06/30/2020)
“Targeting prostaglandin biosynthesis and action in lymphangioleiomyomatosis”

NIH 3P30ES006096 (PI) (09/30/1997 – 03/31/2023) (involvement ended early)
“Center for Environmental Genetics”

 NIH 4R01ES022071 (CoPI) (08/23/2012 – 04/30/2018)
“Effects of Arsenic on Human Prostate Stem Cells and Prostate Cancer Risk”

 NIH R21ES025406 (PI) (04/09/2015 – 03/31/2017)
“Epigenomic effects of perinatal exposure to environmental estrogens promote the development of allergic asthma”

 NIH R56HL130042 (Collaborator) (09/15/2016 – 04/30/2018)
“Autologous cardiomyocytes from masseter muscles to repair myocardial infarction”

Publications

Lu Y, Liu X, Zhang E, Kopras EJ, Smith EP, Astreinidis A, Li C, Leung YK, Ho SM, Yu JJ.  Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells. PLoS One, 15(2) :e0228894, 2020. PMID: 32078667; PMCID: PMC7032738

Ho SM, Lewis JD, Mayer EA, Plevy SE, Chuang E, Rappaport SM, Croitoru K, Korzenik JR, Krischer J, Hyams JS, Judson R, Kellis M, Jerrett M, Miller GW, Grant ML, Shtraizent N, Honig G, Hurtado-Lorenzo A, Wu GD. Challenges in IBD research: Environmental triggers. Inflamm Bowel Dis, 25(Suppl 2): S13-S23, 2019. PMID: 31095702; PMCID: PMC6787673

Khanal T, Leung YK, Jiang W, Timchenko N, Ho SM, Kim K. NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB J, 33(7): 8335-8348, 2019. PMID: 30991008; PMCID: PMC6593879

Xie C, Leung YK, Chen A, Long DX, Hoyo C, Ho SM. Differential methylation values in differential methylation analysis. Bioinformatics. 35(7):1094-1097, 2019.PMID: 30184051: PMCID: PMC6449748

Kim S, Xu X, Zhang Y, Zheng X, Liu R, Dietrich K, Reponen T, Ho SM, Xie C, Sucharew H, Huo X, Chen A. Metal concentrations in pregnant women and neonates from informal electronic waste recycling. J Expo Sci Environ Epidemiol, 29(3): 406-415, 2019. PMID: 30111780: PMCID: PMC6377357

Dworatzek E, Mahmoodzadeh S, Schriever C, Kusumoto K, Kramer L, Santos G, Fliegner D, Leung YK, Ho SM, Zimmermann WH, Lutz S, Regitz-Zagrosek V.  Sex-specific regulation of collagen I and III expression by 17β-Estradiol in cardiac fibroblasts: role of estrogen receptors. Cardiovasc Res, 115(2): 315-327, 2019. PMID: 30016401; PMCID: PMC6933535

Choi H, Dostal M, Pastorkova A, Rossner P Jr, Sram RJ, Ho SM. Greater susceptibility of girls to airborne Benzo[a]pyrene for obesity-associated childhood asthma. Environ Int, 121(Pt 1): 308-316, 2018. PMID: 30237028

Cheong A, Johnson SA, Howald EC, Ellersieck MR, Camacho L, Lewis SM, Vanlandingham MM, Ying J, Ho SM, Rosenfeld CS. Gene expression and DNA methylation changes in the hypothalamus and hippocampus of adult rats developmentally exposed to bisphenol A or ethinyl estradiol: a CLARITY-BPA consortium study. Epigenetics, 13(7): 704-720, 2018.  PMID: 30001178: PMCID: PMC6224219

Leung YK, Ouyang B, Niu L, Xie C, Ying J, Medvedovic M, Chen A, Weihe P, Valvi D, Grandjean P, Ho SM. Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort. Epigenetics. 13(3): 290-300, 2018. PMID: 29560787; PMCID: PMC5997167

Zhang Y, Xu X, Chen A, Davuljigari CB, Zheng X, Kim SS, Dietrich KN, Ho SM, Reponen T, Huo X. Maternal urinary cadmium levels during pregnancy associated with risk of sex-dependent birth outcomes from an e-waste pollution site in China.  Reprod Toxicol, 75: 49-55, 2018. PMID: 29154917

Seeberger J, Grandhi R, Kim SS, Mase WA, Reponen T, Ho SM, Chen A. Special Report: E-Waste Management in the United States and Public Health Implications. J Environ Health, 79(3): 8-16, 2016. PMID: 29120130

Khanal T, Choi K, Leung YK, Wang J, Kim D, Janakiram V, Cho SG, Puga A, Ho SM, Kim K. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep, 7(1): 10662, 2017. PMID: 28878246; PMCID: PMC5587550

Prins GS, Ye SH, Birch L, Zhang X, Cheong A, Lin H, Calderon-Gierszal E, Groen J, Hu WY, Ho SM, van Breemen RB. Prostate cancer risk and DNA methylation signatures in aging rats following developmental BPA exposure: A dose-response analysis. Environ Health Perspect, 125(7): 077007, 2017. PMID: 28728135; PMCID: PMC28728135

Chen T, Lu L, Xu C, Lin X, Leung YK, Ho SM, Ruan XZ, Lian X. Inhibition role of atherogenic diet on ethyl carbamate induced lung tumorigenesis in C57BL/6J cice., Sci Rep, 7(1): 4723, 2017. PMID: 28680122; PMCID: PMC5498653

Sharma M, Zhang X, Zhang S, Niu L, Ho SM, Chen A, Huang S. Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants., Sci Rep,7(1):2085, 2017. PMID: 28522830; PMCID: PMC5437007

Click here to see full list of Dr. Ho’s publications.