William E. Fantegrossi, Ph.D.

FantegrossiAssociate Professor
Phone: 686-8645
Fax: 686-8970
wefantegrossi@uams.edu

Education

Ph.D. – University of Michigan, 2002

Research Interests

In the past few years, a number of relatively obscure compounds have appeared on the illicit drug market. In most cases, these new drugs of abuse have turned out to be established research chemicals that have diffused out of laboratories and scientific journals and onto the streets. As novel pharmacological entities, the legal ramifications for selling and possessing these drugs are initially unclear, and enterprising individuals typically exploit the novelty of these substances to make rapid and substantial profits selling them over-the-counter and online. Indeed, emerging drugs of abuse occupy a legal grey area until emergency scheduling powers are invoked, typically first at the municipal and state level, then nationally.

Research in my laboratory is currently focused on several categories of these drugs, including synthetic cannabinoids (constituents of K2/”Spice” smoking blends), analogues of cathinone (present in “bath salts” preparations), hallucinogens (related to mescaline) and novel opioids (including extremely potent fentanyl analogues.) In an effort to better understand the biological actions of these emerging drugs of abuse, we use behavioral pharmacology techniques in rodents to compare these compounds with more the well-known drugs of abuse which these emerging drugs are designed to mimic (such as the phytocannabinoid delta9-THC, psychostimulants like MDMA and methamphetamine, research psychedelics like DOI, and traditional opioids like fentanyl and morphine).

Students interested in working in my laboratory will have the opportunity to assist with surgeries (intraperitoneal implantation of biotelemetry probes which simultaneously measure core temperature and locomotor activity), to work with mice or rats in behavioral assays (including operant tests of food- or drug-maintained responding, and assays of drug-elicited effects such as analgesia and catalepsy), and assist with dissections for studies involving tissue distribution and disposition of drug, neurotoxicity, or molecular correlates of tolerance and withdrawal.

Meet Dr. Fantegrossi’s Research Team

Recent Research Support

Current Research
DEA/FDA HHSF223201610079C (PI) (09/12/16 – 09/11/21)
“In Vivo Pharmacological Studies for abuse liability testing”

ASPET  (Director)  (06/01/17 – 05/31/20)
“ASPET Summer Undergraduate Research Fellowship”

NIH/NIDA R01 DA039143 (Co-I) (10/01/15 – 09/30/20)
“Synthetic cannabinoid toxicity: role of biotransformation”

NIH/NIDA R01 DA039195 (Co-I) (05/01/15 – 03/31/20)
“Pharmacology and therapy for MDPV and alpha-PVP like drugs of abuse”

NIH/NIGMS P30 GM110702  (Director, Behavioral Core)  (01/05/14 – 04/30/19)
“Center for Translational Neuroscience”

NIH/NIDA T32 DA022981 (Director, Summer Med Stdt Internship) (01/07/15 – 06/30/19)
“Translational Training in Addiction”

Completed Research

NIH/NIDA R01 DA036600 (Co-I) (01/07/14 – 06/30/18)
“Gene therapy for the treatment of methamphetamine abuse”

Publications

Yadlapalli JSK, Bommagani SB, Mahelona RD, Wan A, Gannon BM, Penthala NR, Dobretsov M, Crooks PA, Fantegrossi WE. Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6-O-sulfate in rats: Drug discrimination and physical dependence. Pharmacol Res Perspect. 6(4):e00403, 2018. PMID: 29930811

Mu S, Fantegrossi WE, Rusch NJ. Cocaine-Responsive miRNA and Blood Pressure Elevation. Hypertension. 71(4):561-562, 2018. PMID: 29483229

Fantegrossi WE, Wilson CD, Berquist MD. Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin, and glutamate systems. Drug Metab Rev. 50(1):65-73, 2018. PMID: 29385930

Gannon BM, Williamson A, Rice KC and Fantegrossi WE. Role of monoaminergic systems and ambient temperature in bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV)-elicited hyperthermia and locomotor stimulation in mice. Neuropharmacology. S0028-3908(17)30422-7, 2018. PMID: 28887185

Gannon BM, Russell LN, Modi MS, Rice KC and Fantegrossi WE. Effects of orally self-administered bath salt constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice. Drug Alcohol Depend. 179:408-415, 2017. PMID: 28866386

Ford BM, Franks LN, Tai S, Fantegrossi WE, Stahl EL, Berquist MD, Cabanlong CV, Wilson CD, Penthala NR, Crooks PA and Prather PL. Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development. Pharmacol Res. 125(Pt B):161-177, 2017. PMID: 28838808

Berquist MD, Hyatt WS, Bauer-Erickson J, Gannon BM, Norwood AP and Fantegrossi WE. Phencyclidine-like in vivo effects of methoxetamine in mice and rats. Neuropharmacology. S0028-3908(17)30395-7, 2017. PMID: 28830759

Lantz SM, Rosas-Hernandez H, Cuevas E, Robinson B, Rice KC, Fantegrossi WE, Imam SZ, Paule MG and Ali SF. Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study. Neurosci Lett. 655:76-81, 2017. PMID: 28684237

Berquist MD and Fantegrossi WE. Discriminative Stimulus Effects of Psychostimulants. Curr Top Behav Neurosci. EPub doi: 10.1007/7854_2017_5, 2017. PMID:28341944

Ford BM, Tai S, Fantegrossi WE and Prather PL. Synthetic Pot: Not Your Grandfather’s Marijuana. Trends Pharmacol Sci. 38(3):257-276, 2017. PMID: 28162792

Tai S and Fantegrossi WE.  Pharmacological and Toxicological Effects of Synthetic Cannabinoids and Their Metabolites. Curr Top Behav Neurosci. 32:249-262, 2017. PMID: 28012093

Rosas-Hernandez H, Cuevas E, Lantz SM, Rice KC, Gannon BM, Fantegrossi WE, Gonzalez C, Paule MG, Ali SF. Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells. Neurosci Lett. 629:125-30, 2016. PMID: 27320055

Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. PLoS One. 11(3):e0150602, 2016. PMID: 26963248

Gannon BM, Williamson A, Suzuki M, Rice KC, Fantegrossi WE. Stereoselective Effects of Abused “Bath Salt” Constituent 3,4-Methylenedioxypyrovalerone in Mice: Drug Discrimination, Locomotor Activity, and Thermoregulation. J Pharmacol Exp Ther. 356(3):615-23, 2016. PMID: 26769917

Tai S, Hyatt WS, Gu C, Franks LN, Vasiljevik T, Brents LK, Prather PL, Fantegrossi WE. Repeated administration of phytocannabinoid Δ(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner. Pharmacol Res. 102:22-32, 2015. PMID: 26361728

View Dr. Fantegrossi’s Publication List