Recent Graduates

Ryan Macleod, Ph.D.

Graduation Date:  August 15, 2019 (supported by SPaT Institution Match)

Dissertation Title: Novel use of CRISPR technology to investigate bone biology

Current Position: 3rd year medical student completing the MD portion of the MD/PhD degree

Recent Publications:  Click for a full list of Dr. MacLeod’s publications.

Samantha McClenahan, Ph.D.

Graduation Date:  June 19, 2019 (supported by SPaT T32 GM106999)

Dissertation Title: Development and testing of a vaccine for 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinovalerophenone (α-PVP)

Current Position:  Postdoctoral fellow at Vanderbilt University

Recent Publications:  Click for a full list of Dr. McClenahan’s publications.

McClenahan SJ, Hambuchen MD, Simecka CM, Gunnell MG, Berquist MD, Owens SM. Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats. Drug Alcohol Depend. 195: 140-147, 2019.

Hambuchen MD, Hendrickson HP, Gunnell MG, McClenahan SJ, Ewing LE, Gibson DM, Berquist MD, Owens SM. The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in femaile and male rats. Drug Alcohol Depend. 179: 347-354, 2017.

Bill Hyatt, Ph.D.

Graduation Date:  May 28, 2019 (supported by SPaT institution match)

Dissertation Title:  Acute and persistent impulsive effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV)

Current Position:  3rd year medical student completing the MD portion of the MD/PhD degree

Recent Publications:  Click for a full list of Dr. Hyatt’s publications.

Hyatt WS, Berquist MD, Chitre NM, Russell LN, Rice KC, Murnane KS, Fantegrossi WE. Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats.  Behav Pharmacol. doi: 10.1097/FBP.0000000000000492. [Epub ahead of print], 2019.

Berquist MD, Hyatt WS, Bauer-Erickson J, Gannon BM, Norwood AJ, Fantegrossi WE.  Phencyclidine-like in vivo effects of methoxetamine in mice and rats. Neuropharmacology. 134(Pt A): 158-166, 2018.

Daniel Meeker, Ph.D.

Graduation Date:  February 15, 2018 (supported by SPaT institution match)

Dissertation Title: Development of a targeted nanotherapeutic approach to the treatment of biofilm-associated Staphylococcus aureus infection

Current Position:  4th year medical student completing the MD portion of the MD/PhD degree

Recent Publications:  Click for a full list of Dr. Meeker’s publications.

Meeker DG, Cooper KB, Renard RL, Mears SC, Smeltzer MS, Barnes CL. Comparative Study of Antibiotic Elution Profiles From Alternative Formulations of Polymethylmethacrylate Bone Cement. J Arthroplasty. pii: S0883-5403(19)30231-1, 2019.

Blom A, Cho J, Fleischman A, Goswami K, Ketonis C, Kunustor S, Makar G, Meeker DG, Morgan-Jones R, Ortega-Peña S, Parvizi J, Smeltzer M, Stambough JB, Urish K, Tonelo Zilotto GP. General Assembly, Prevention, Antiseptic Irrigation Solution: Proceedings of International Consensus on Orthopedic Infections. J Arthroplasty. pii: S0883-5403(18)30846-5, 2018.

Zakeyah AA, Whitt J, Duke C, Gilmore DF, Meeker DG, Smeltzer MS, Alam MA. Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid. Bioorg Med Chem Lett. 2018. 28(17):2914-2919, 2018.

Alex W. Alund, Ph.D.

Graduation Date:  June 10, 2016 (supported by SPaT T32 GM106999)

Dissertation Title: The role of reactive oxygen species in alcohol-induced osteopenia and the regulation of bone turnover

Current Position: Laboratory Safety and Building Coordinator, Arkansas Department of Health

Recent Publications:  Click for a full list of Dr. Alund’s publications.

Yang CS, Mercer KE, Alund AW, Suva LJ, Badger TM, Ronis MJ. Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Exp Biol Med. 239:1380-9 2014.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen JR, Badger TM, Van Remmen H, Ronis MJ. Reactive oxygen species differentially regulate bone turnover in an age-specific manner in catalase transgenic female mice. J Pharmacol Exp Ther. 358:50-60, cover photograph, 2016.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen JR, Badger TM, Ronis MJ. Protections by dietary antioxidants against ethanol-Induced osteopenia and changes in bone morphology in female mice. Alcoholism: Clinical and Experimental Research (in press).

Clark R. Sims, Ph.D.

Graduation Date:  November 4, 2016 (supported by SPaT T32 GM106999)

Dissertation Title: Preclinical studies of targeted therapy in an infant model of sepsis-induced cardiorenal syndrome

Current Position: Senior Research Associate, Arkansas Children’s Nutrition Center

Recent Publications: Click for a full list of Dr. Sims’ publications.

Mercer KE, Sims CR, Yang CS, Wynne RA, Moutos C, Hogue WR, Lumpkin CK, Suva LJ, Chen JR, Badger, TM, Ronis MJ. Loss of functional NADPH oxidase 2 protects against alcohol-induced bone resorption in female p47phox-/- mice. Alcohol Clin Exp Res. 38:672-82, 2014.

Sims CR, MacMillan-Crow LA, Mayeux PR. Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis. Clin Pharmacol Ther. 96:662-4, 2014.

Wang Z, Sims CR, Patil NK, Gokden N, Mayeux PR. Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther. 352(1):61-6, 2015.

Sims CR, Nguyen TC, Mayeux PR. Could biomarkers direct therapy for the septic patient? J Pharmacol Exp Ther. 357:228-39. 2016.

Emily R Holthoff, Ph.D.

Graduation Date:  May 2, 2016 (supported by SPaT institution match)

Dissertation Title: Identifying Pathologic and Molecular Features that Predict Adverse Clinical Outcomes in Vulvar Squamous Cell Carcinoma

Current Position: Resident Physician at University of Arkansas for Medical Sciences

Recent Publications: Click for a full list of Dr. Holthoff’s publications.

Holthoff ER, Jeffus SK, Gehlot A, Stone R, Erickson SW, Kelly T, Quick CM, Post SR. Perineural invasion is an independent pathologic indicator of recurrence in vulvar squamous cell carcinoma. Am J Surg Pathol. 39:1070-4, 2015.

Jeffus SK, Gehlot A, Holthoff ER, Stone R, Spencer H, Kelly T, Post SR, Quick CM. A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. Am J Surg Pathol. 39:1226-33, 2015.

Mazur A, Holthoff ER, Vadali S, Kelly T, Post SR. Cleavage of type I collagen by fibroblast activation protein-α enhances class A scavenger receptor mediated macrophage adhesion. PLoS One. e0150287, 2016.

Holthoff ER, Spencer H, Kelly T, Post SR, Quick, CM. Pathologic features of aggressive vulvar squamous cell carcinoma are associated with an epithelial-mesenchymal transition. Hum Pathol. 56:22-30, 2016.

Predoctoral fellowships awarded to trainees:

  • Brian Koss – NRSA NIH F31 CA232464 “Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes” (2019-2022)
  • Laura Ewing – PhRMA Foundation Predoctoral Fellowship “Role of methionine-gut microbiome interaction in radiation-induced gastrointestinal toxicity” (2019-2020)
  • Samantha McClenahan – NRSA NIH F31 DA046121 “Development of an enantiomeric specific vaccine for 3,4-methylenedioxypyrovalerone (MDPV) abuse” (2018-2021)
  • Julia Tobacyk – PhRMA Foundation Predoctoral Fellowship “The therapeutic role of OMA1 in cold storage induced nephrotoxicity” (2018-2020)
  • Stephen Shrum – American Heart Association Predoctoral 16PRE30830010 “Role of mitoBK channels in rat renal cold preservation” (2016-2018)
  • Lascelles Lyn-Cook, Jr. – Southern Regional Education Board Doctoral Scholars (2016-2017)
  • Clark Sims – NRSA NIH F31 DK104533 “Targeting renal perfusion and mitochondrial oxidants in a model of infant sepsis” (2015-2016)
  • Clark Sims – American Heart Association Predoctoral 15PRE20450050 “Renal microcirculatory failure in a rat pup model of pediatric sepsis” (2014)
  • Daniel Meeker – NRSA NIH F31 (recommended for funding, 2017)

Time to degree for SPaT trainees (Ph.D. only):

4.6 years