John Arthur, M.D., Ph.D.John Arthur, M.D., Ph.D.
Professor and Director, Division of Nephrology, Department of Internal Medicine, College of Medicine

I am a practicing nephrologist with a strong interest in acute kidney disease and have been using proteomic technologies for discovery and validation of biomarkers for over 15 years.   We use targeted analysis of candidate markers by multiplexed bead array, ELISA and mass spectrometry and proteomic discovery analyses by liquid chromatography/mass spectrometry to identify and qualify biomarkers.

Nukhet Aykin-Burns, Ph.D.Nukhet Aykin-Burns, Ph.D.
Associate Professor, Department of Pharmaceutical Sciences, College of Pharmacy

As a researcher, my primary interest is the effects of environmental toxins, such as lead and PCBs, on oxidative stress and the effects of mitochondrial dysfunction and oxidative stress on radiation-induced normal tissue damage. I am currently funded by NIEHS to assess the role of sirtuin 3 in regulating PCB-induced mitochondrial injury through AREA Grant mechanism, which is instrumental for exposing students to research.

Steven W. Barger, Ph.D.Steven W. Barger, Ph.D.
Professor of Geriatrics, Professor of Neurobiology & Developmental Sciences, College of Medicine

My projects focus on links between glucose and insulin metabolism in processes leading to the development of Alzheimer’s disease.  This age-related neurodegenerative disease is the most common cause of dementia and seems to depend on the accumulation of a peptide termed “amyloid-β.”  Our studies utilize experiments conducted in cultured cells and models developed in mice, particularly mice genetically altered for amyloid-β along with diet-induced obesity.  These studies may provide key insights into the cause(s) and treatment of both Alzheimer’s disease and perhaps even diabetes.

Alexei Basnakian, M.D., Ph.D.
Professor, Dept of Pharmacology and Toxicology, College of Medicine

I am mostly interested in apoptotic endonucleases, the key enzymes regulating irreversible cell death after cell injury and during diseases. The nine known endonucleases seem to act by fragmenting DNA independently from each other. Our latest studies show the crosstalk between the endonucleases through several mechanisms. When necessary, tissues can protect themselves by inactivating endonucleases, while in other cases, the endonucleases activate each other and cooperate. By learning the mechanisms of this regulation, we hope to find universal cures of many human diseases including organ failures and cancers.

Sarah Blossom, Ph.D.Sarah Blossom, Ph.D.
Associate Professor, Department of Pediatrics, College of Medicine

My research goal is to advance understanding of how environmental exposures, primarily the solvent and common environmental pollutant, trichloroethylene (TCE) alter CD4+ T cell function.  My expertise lies in development/early life exposures.  I am interested in understanding how these exposures impact both mother and offspring.  My research has shown that the CD4+ T cell is central to the autoimmune pathology we see in the liver with TCE exposure.

Karl Boehme, Ph.D.Karl Boehme, Ph.D.
Associate Professor, Department of Microbiology and Immunology, College of Medicine

Research in my laboratory focuses on defining mechanisms of viral pathogenesis using mammalian orthoreovirus (reovirus) as a model system. Reoviruses are enteric pathogens that enter the bloodstream to disseminate to the central nervous system where they cause encephalitis. We work to define host and viral determinants that govern (i) the establishment of viral bloodstream infections and (ii) development of viral encephalitic disease.

Marjan Boerma, Ph.D.
Associate Professor, Dept of Pharmaceutical Sciences, College of Pharmacy

Radiation-induced heart disease is a late occurring and sometimes severe side effect of radiotherapy of cancers in the thorax. To better understand how radiation causes heart disease, our lab uses preclinical in vivo models to study the effects of radiation on cardiac function, structure and molecular changes.

Gunnar Boysen, Ph.D.
Associate Professor, Environmental and Occupational Health, College of Public Health

My interest is understanding the interplay between chemical exposure and nutritional or lifestyle habits, (diet selection and physical activity). We utilize small metabolomic biomarkers to characterize disease phenotypes.

Peter Crooks, Ph.D.
Professor and Chair, Dept of Pharmaceutical Sciences, College of Pharmacy

My research is focused on the design and discovery of treatments for cancer and drug addiction, as well as aspects of prodrug and codrug design, drug metabolism studies, and the pharmacokinetic evaluation of potential clinical candidates.

FantegrossiWilliam Fantegrossi, Ph.D.
Associate Professor, Dept of Pharmaocology and Toxicology, College of Medicine

My research focuses on the behavioral pharmacology of emerging drugs of abuse, including designer psychostimulants (“bath salts”), cannabinoids (“K2 / Spice” products), and hallucinogens. We employ a variety of in vivo assays to study drug actions, including biotelemetry, intravenous drug self-administration, conditioned place preference, drug discrimination, operant behavior, antinociception, and drug-elicited behaviors.

Sherry Ferguson, Ph.D.
Adjunct Associate Professor, Dept of Pharmacology and Toxicology, National Center for Toxicological Research

I am particularly interested in the effects of developmental exposure to drugs/toxicants on central nervous system functioning; however, a main focus of my laboratory now is the potential of certain compounds to attentuate the neurochemical and behavioral alterations in a transgenic mouse model of Alzheimer’s Disease.  Typical endpoints in these studies include a wide range of rodent behaviors as well as neurochemical data from in vivo cerebral microdialysis experiments.

Aime Franco, Ph.D.Aime Franco, Ph.D.
Associate Professor, Physiology and Biophysics, College of Medicine

The goal of my research lab is to understand how the tumor microenvironment impacts cancer growth and metastasis.  We are particularly interested in how fibroblasts and immune cells within the tumor can communicate with each other to drive tumor progression and metastasis.  We utilize a variety of in vitro and in vivo models to dissect the dynamic crosstalk between cancer cells and normal cells.  We work closely with physicians in the Cancer Institute to try and translate our laboratory findings into improved patient care.

Jay Gandy, Ph.D.
Professor and Chair, Environmental and Occupational Health, College of Public Health

My research interests are pesticide toxicology, human health risk assessment, and the application of basic mechanistic studies to regulatory decision-making.

GottschallPaul Gottschall, Ph.D.
Professor, Department of Pharmacology and Toxicology, College of Medicine

The goal of my research program is to elucidate how changes in extracellular matrix in the brain influence the decline in neural plasticity observed with aging, and in particular, to determine whether proteoglycans contribute to the diminished structural synaptic plasticity associated with Alzheimer’s disease.

Martin Hauer-Jensen, M.D., Ph.D., F.A.C.S.
Professor and Director of Radiation Health and Associate Dean for Research, Dept of Pharmaceutical Sciences, College of Pharmacy

My research focuses on radiation effects in normal tissues, mainly in the gastrointestinal tract. The overall goal is to determine underlying mechanisms of normal tissue radiation toxicity and to develop strategies to prevent adverse effects of radiation therapy in cancer survivors. I am also actively involved in the development of medical countermeasures against radiological or nuclear threats.

Charlotte Hobbs, M.D., Ph.D.Charlotte Hobbs, M.D., Ph.D.
Pamela D. Stephens Professor of Birth Defects Research and Section Chief, Birth Defects Research, Dept of Pediatrics, College of Medicine; Arkansas Children’s Hospital

My research focus is to increase the understanding of the causes of birth defects so that we can intervene and prevent them  in the future. My team is identifying genetic and metabolic markers to identify women who are at increased risk of having a pregnancy/fetus affected by a congenital heart defect.  By discovering life-style factors, genetic variants and metabolic markers that may lead to congenital heart defects, primary prevention methods may be developed.

Laura James, M.D.
Professor, Department of Pediatrics, College of Medicine; Arkansas Children’s Hospital

I have clinical and translational research programs in acetaminophen toxicity that are funded by the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK).  My research focuses on the development of biomarkers of acetaminophen toxicity using systems biology approaches involving genomics, metabolomics, and proteomics.  I am also developing a new diagnostic assay for acetaminophen toxicity.

Clint Kilts, Ph.D.
Professor, Department of Psychiatry, College of Medicine

My primary research interests focus on the use of brain imaging approaches to explore the impact of drugs of abuse and medications on human functional brain organization.  Additionally, research in the BIRC also focuses on development of reliable and accurate biomarkers of risk, diagnosis, and treatment outcome for mental illness.

Igor Koturbash, M.D., Ph.D.Igor Koturbash, M.D., Ph.D.
Associate Professor, Department of Occupational and Environmental Health, College of Public Health

The focus of my research interests is in understanding of the epigenetic effects and mechanisms of normal and cancerous tissue response to cancer therapy, and how the modification over the epigenetic profile may modulate tissue response to therapy.  I have a broad background in molecular and radiation biology, with specific training in epigenetic mechanisms of response to radiation exposure in both in vitro and in vivo systems.

Richard Kurten, Ph.D.Richard Kurten, Ph.D.
Associate Professor, Department of Physiology and Biophysics, College of Medicine and Co-Director, Lung Cell Biology Laboratory, Arkansas Children’s Hospital

My vision is that cell biological approaches largely restricted to cultured cell lines can be used to study human biology in a native tissue context.    A focus of my research interests is on understanding mechanism contributing to airway hyper-reactivity and the development of tolerance to beta-agonist medications used clinically to manage asthma.

Annie Lumen, Ph.D.Annie Lumen, Ph.D.
Staff Fellow, Division of Biochemical Toxicology, National Center for Toxicological Research

My current research focuses on the development of computational (PK/PD/Dose-Response) models for drugs and environmental chemicals as a reliable predictive tool to support relevant regulatory decisions. Such models have the capability to conduct cross-species extrapolation, in vitro to in vivo extrapolations, and quantitate life-stage dependent kinetic alternations to guide dose selection during pregnancy and support other risk assessment needs of the agency and the scientific field.

Lee Ann MacMillan-Crow, Ph.D.
Professor, Dept of Pharmaocology and Toxicology, College of Medicine; Director of Pharmacology and Toxicology/Interdisciplinary Toxicology Graduate Program

My lab has a long-term interest in oxidant generation and mitochondrial damage during renal ischemia/reperfusion as it relates to renal transplantation injury. In addition, the lab is examining the therapeutic potential of several agents to block mitochondrial and renal injury during warm and cold ischemia using animal models of ischemia, as well as sepsis.

William Mattes, Ph.D.William Mattes, Ph.D.
Professor and Director, Division of Systems Toxicology, National Center for Toxicological Research

My research focuses on using biomarkers of responses to toxicity and pathology across species to inform the use of modeling in vitro and in vivo systems for human safety assessment.

Philip Mayeux, Ph.D.
Professor, Dept of Pharmacology and Toxicology, College of Medicine; Director of SPaT Program

The goals of my research are to identify new therapeutic targets to treat sepsis-induced kidney injury then test agents that target these new pathways. Students will receive training in the use of juvenile and aged rodent models of sepsis, in evaluating cardio/renal function, the kidney microcirculation, mitochondrial function, and in performing pre-clinical drug evaluation studies.

Mitchell R. McGill, Ph.D.
Assistant Professor, Department of Environmental and Occupational Health, Fay W. Boozman College of Public Health

Our laboratory studies the fundamental mechanisms of liver injury and repair, particularly drug-induced liver injury. Our major goals are to identify and characterize 1) new drug targets to treat liver disease patients, 2) new biomarkers for prognosis in acute liver failure and 3) new methods for pre-clinical prediction of drug hepatotoxicity. We heavily rely on the murine model of acetaminophen overdose to accomplish those goals, though other models are also available in our laboratory. Additional interests include the pathophysiology of fatty liver diseases, and extrahepatic toxicity of acetaminophen.

Grover P Miller, PhD
Professor, Department of Biochemistry and Molecular Biology, College of Medicine

The goals of my research are to assess and interpret the biological significance of metabolic activation and clearance of molecules especially in relation to pharmacological and toxicological effects on humans. In practice, my group leverages powerful analytical and biochemical tools to identify and quantitate small molecules including drugs, pollutants, and food additives as they undergo transformations through metabolic pathways and then correlate findings to biological activity and in vivo outcomes. Individual projects aim to (1) determine metabolic mechanisms and efficiencies for the activation and elimination of potentially toxic molecules, (2) phenotype enzymes responsible for metabolic pathways that account for variation in the population and confound the identification of toxicological mechanisms, (3) profile metabolites in humans and animal models to correlate in vitro findings to in vivo outcomes and potentially identify diagnostic biomarkers, and (4) develop computational models for metabolic activation and clearance of drugs contributing to adverse drug events to improve their safety for patients.

JMoraneffery Moran, Ph.D.
Assistant Professor, Department of Pharmacology and Toxicology, College of Medicine; Department of Environmental and Occupational Health, College of Public Health

My research involves the detection and mechanisms of drugs of abuse, environmental toxicants, endogenous molecules and other xenobiotics. The analytical platforms developed are often used to support forensic, public health, and environmental laboratories.

Shengyu Mu, Ph.D.
Assistant Professor, Department of Pharmacology and Toxicology, College of Medicine

The primary interest of my research has been focusing on the pathogenesis of hypertension in renal salt-reabsorption and the systemic vasculature. The long-term goal of our laboratory is to understand the mechanism of the development of hypertension and to translate our basic scientific discovery to clinics to contribute to a final cure for hypertension. Our most recent project is investigating the role and molecular mechanisms of immunity in stimulating salt/volume retention in the kidney, which contributes to the pathogenesis of salt-sensitive hypertension. We have acquired techniques and research experience involved in most areas of physiology, molecular biology, genetics, epigenetics, histology and vascular biology that are needed to pursue our goal of translational medicine.

Charles O’Brien, Ph.D.
Professor, Department of Internal Medicine, Division of Endocrinology

Our research focuses on the cellular and molecular mechanisms that control bone remodeling and lead to osteoporosis.  We have generated several novel genetically-modified mouse models. Trainees in my lab benefit from access to state-of-the-art techniques to modify the mouse genome and my experience in using these techniques to generate informative models of bone disease.

 S. Michael Owens, Ph.D.
Professor, Department of Pharmacology and Toxicology, College of Medicine

Research in my laboratory involves experimental therapeutics and preclinical development of antibody-based medications for the treatment of drug abuse. Our first medication, an anti-methamphetamine monoclonal antibody, is currently in an FDA approved clinical trial.

 Eric Peterson, Ph.D.
Associate Professor, Department of Pharmacology and Toxicology, College of Medicine

The focus of my research is to develop novel biologic medications to treat chronic and acute drug abuse.   We are accomplishing this goal through a multidisciplinary drug development program. The students in my laboratory gain an understanding of in vitro molecular-based design and production of biological entities, and in vivo testing of their safety and efficacy in models of dug abuse and addiction.

Steven Post, Ph.D.
Professor, Department of Pathology, College of Medicine

The goal of our research is to understand the key role that macrophages play in the development and progression of chronic inflammatory diseases. In particular, our studies seek to provide mechanistic details regarding the ability of macrophage scavenger receptors to regulate the inflammatory response associated with cardiovascular disease and cancer.

Paul Prather, Ph.D.
Professor, Dept of Pharmaocology and Toxicology, College of Medicine

My research interests involve understanding the neurobiological mechanisms underlying the addictive states produced by drugs of abuse. Specifically, I investigate the cellular and molecular mechanisms of signal transduction mediated by G-protein coupled receptors (GPCRs) with which drugs of abuse interact. I have recently shown that active phase I hydroxylated metabolites of synthetic cannabinoids present in K2/Spice may contribute to the rather unique toxicity profile associated with use of these drugs. As such, my laboratory provides students with the opportunity to employ cellular and molecular techniques to characterize the pharmacological and toxicological properties of novel drugs of abuse.

RheeSung Rhee, Ph.D.
Associate Professor, Dept of Pharmacology and Toxicology, College of Medicine

The overall goal of my research is to understand how ion channels are regulated in blood vessels and apply this knowledge to design better antihypertensive therapies. We use rodent models of hypertension and apply viral gene transduction and in vivo microscopy among other techniques.

Kevin Raney, Ph.D.Kevin Raney, Ph.D.
Professor and Chair, Dept of Biochemistry and Molecular Biology, College of Medicine

My laboratory is interested in the enzymology and chemistry of nucleic acid enzymes.  Helicases are enzymes that manipulate DNA and RNA in all aspects of nucleic acid metabolism.  We are studying the mechanism(s) of helicases as well as protein-protein that govern activity.  We have identified novel compounds that inhibit NS3 helicase from the Hepatitis C virus.  In a separate project, we have discovered a signaling mechanism by which cells respond to DNA damage.

Rusch Nancy Rusch, Ph.D.
Professor and Chair, Dept of Pharmacology and Toxicology, College of Medicine

The goal of my laboratory is to discover abnormalities of ion channel expression and composition that contribute to systemic and pulmonary hypertension, and identify channel-based therapies to treat these diseases. We employ a multi-faceted approach of patch-clamp, molecular, cellular and in vivo techniques to accomplish this goal.

Maria Schuller Almeida, PhD
Professor, Department of Internal Medicine, Department of Orthopedic Surgery, College of Medicine

The overall goal of my research is to elucidate the cellular and molecular mechanisms responsible for skeletal aging. We employ genetically modified mouse models, pharmacological and cell culture approaches to unravel the molecular pathways that mediate the effects of sex steroid deficiency and old age on bone. Particular emphasis is given to the contribution of common aging mechanisms such as oxidative stress and cellular senescence.

Mark Smeltzer, Ph.D.
Professor, Dept of Microbiology and Immunology, College of Medicine

My research is on the detection, treatment, and pathogenesis of Staphylococcus aureus infection with a specific emphasis on infections involving bone and indwelling medical devices. I am the recipient of the New Investigator Award from the Orthopaedic Research Society and the Randall Award as the Outstanding Young Investigator from the South Central Branch of the American Society for Microbiology (ASM).  I am currently an ASM Distinguished Lecturer and was recognized as the 2013 recipient of the UAMS Distinguished Faculty Scholar Award.

Alan Tackett, Ph.D.Alan Tackett, Ph.D.
Professor, Biochemistry and Molecular Biology, College of Medicine

My research focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We also develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone-modifying proteins.

David W. Ussery, Ph.D.David W. Ussery, Ph.D.
Professor, Biomedical Informatics/Physiology and Biophysics, College of Medicine;  Director, Arkansas Center for Genomic Epidemiology and Medicine

My research focusses on high-throughput comparative genomics, developing tools to compare millions of genomes in a few seconds.  We are developing methodologies where we can take a clinical isolate like blood or a fecal sample, and determine the microbial composition, including possible toxins and antibiotic resistance, in less than an hour. Our goal is to model microbial ecosystems within healthy and diseased people. Students in my group work both in the lab as well as using high performance computing for bioinformatic analysis.