Systems Pharmacology and Toxicology (SPaT) Fifth Annual Symposium

May 10, 2018
9:00 a.m. – 3:00 p.m.
Walton Auditorium, Winthrop P. Rockefeller Cancer Institute

The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its fifth annual symposium featuring presentations by SPaT trainees and students and postdocs from various graduate programs presented posters.   The keynote presentation was given by Sarah England, Ph.D. (Washington University School of Medicine).

Group picture from symposium

8:00-9:00 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant

9:10-9:35 AM
“In vivo and computational modeling of methionine disposition and interactions effects with radiation-induced toxicity”
Laura Ewing, SPaT T32 Traiinee, Pharmacology, Toxicology and Experimental Therapeutics GPIBS Track

9:35-10:00 AM
“Inhibiting PARP-1 signaling of DNA repair by decoy G4 DNA activation”
Lucas DeYoung, SPaT T32 Trainee, Biochemistry and Molecular Biology Graduate Track

10:00-10:25 AM
“Histone H3 epigenetic switch drives metabolic reprogramming in tumor-infiltrating lymphocytes”
Brian Koss, SPaT COM/TRI Trainee, Biochemistry and Molecular Biology Graduate Track

10:25-10:50 AM
“ATP-sensitive potassium channel openers inhibit the rhythmic contractions of rat mesenteric lymph vessels and attenuate lymph flow”
Brittney Garner, SPaT T32 Trainee, Interdisciplinary Toxicology Graduate Program

10:50-11:00 AM
Break/Poster Viewing

11:00-11:25 AM
“Modeling barrier dysfunction relevant to eosinophilic esophagitis (EOE) in human esophageal explant cultures”
Dolapo Adejumobi, SPaT T32 Trainee, Interdisciplinary Toxicology Graduate Program

11:50-12:15 PM
“Use of CRISPR/Cas9 system to modulate endogenous gene transcriptional activity”
Ryan MacLeod, SPaT COM/TRI Trainee, Interdisciplinary Biomedical Sciences Graduate Program

12:15-12:45 PM
Luncheon

12:45-1:30 PM
Poster Viewing

1:30-2:30 PM
Keynote Presentation- Sarah England, Ph.D.
Professor Obstetrics and Gynecology
Alan A. and Edity L. Wolff Professor of Medicine
Associate Director, Center for Reproductive Health Services
Washington University school of Medicine in St. Louis
“Translational Studies on the Oxytocin Receptor: A Personalized Medicine Approach”

2:30-3:00 PM
Closing Remarks and Final Poster Viewing

Keynote speaker bio

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Systems Pharmacology and Toxicology (SPaT) Fourth Annual Symposium

May 9, 2017
9:00 a.m. – 3:00 p.m.
Walton Auditorium, Winthrop P. Rockefeller Cancer Institute

The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its fourth annual symposium featuring presentations by SPaT trainees and students from PCOL, INTX and IBS programs.   The keynote presentation was given by James H. Woods, PhD (University of Texas Health Science Center at San Antonio)

Students at Symposium

9:00-9:10 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant

9:10–9:35 AM
“Cardiovascular and locomotor effects of 3/4-methylenedioxypyrovalerone (MDPV)
in male and female Sprague-Dawley (SD) rats”
Samantha McClenahan, SPaT Trainee, Interdisciplinary Toxicology Graduate Program

9:35—10:00 AM
“Measuring barrier function in human esophageal mucosa”
Dolapo Adejumobi, SPaT Trainee, IBS Graduate Program

10:00 ‐10:25 AM
“Influence of KATP Channels on the Contractile Properties of Rat Mesenteric Lymph Vessels”
Brittney Garner, SPaT Trainee, Interdisciplinary Toxicology Graduate Program

10:25 ‐10:50 AM
“Use of the CRISPRi/dCas9::KRAB system to suppress gene expression”
Ryan MacLeod, COM/TRI Trainee, IBS Graduate Program

10:50-11:00 AM
Break/Poster Viewing

11:00 ‐11:25 AM
Novel interaction between a mitochondrial chaperone and protease during renal transplantation”
Julia Tobacyk, SPaT Trainee, Pharmacology Graduate Program

11:25 ‐11:50 AM
“The role of MitoBK channels in renal cold preservation”
Stephen Shrum, Former SPaT Trainee, IBS Graduate Program

11:50 ‐12:15 AM
“Training and development: Impulsive choice for milk reinforcement to predict drug abuse liability in rats”
Bill Hyatt, Former COM/TRI Trainee, IBS Graduate Program

12:15 – 12:45 PM
Luncheon

12:45 – 1:30 PM
Poster Viewing

1:30 – 2:30 PM
Keynote Presentation – James H. Woods, Ph.D.
Research Professor, Department of Pharmacology
University of Texas Health Science Center at San Antonio
“Behavioral discoveries related to cholinergic pharmacology”

2:30 – 3:00 PM
Closing Remarks and Final Poster Viewing

Flyer - James H. Woods, Ph.D.


 Systems Pharmacology and Toxicology (SPaT) Third Annual Symposium

May 10, 2016
9:00 a.m. – 2:30 p.m.
Walton Auditorium, Winthrop P. Rockefeller Cancer Institute

The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its third annual symposium featuring presentations by the six 2015-2016 SPaT trainees, poster presentations by the three previous trainees and students from PCOL, INTX and IBS programs, as well as graduate students of SPaT Training Faculty.   The keynote presentation was given by Vishal Vaidya, Ph.D. (Harvard Medical School)

SPaT trainee group

9:00-9:10 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant

9:10–9:35 AM
“Population variability in cisplatin-induced kidney injury outcomes are modeled using diversity outbred mice”
Julia Tobacyk, SPaT Trainee, Pharmacology Graduate Program

9:35—10:00 AM
“The role of mitoBK channels in renal cold preservation”
Stephen Shrum, SPaT Trainee, IBS Graduate Program

10:00 ‐10:25 AM
“The development of Anti-METH immunotherapies using adeno-associated viruses”
Chuck Hay, SPaT Trainee, Interdisciplinary Toxicology Graduate Program

10:25-10:40 AM
Break/Poster Viewing

10:40 ‐11:05 AM
“Effects of synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and
α-pyrrolidinovalerophenone (α-PVP) on impulsivity and vulnerability to psychostimulant abuse”
Bill Hyatt, COM/TRI Trainee, IBS Graduate Program

11:05 ‐11:30 AM
“Genetic background plays a role in risk of zileuton-induced liver injury in diversity outbred mice”
Lascelles Lyn-Cook Jr., SPaT Trainee, IBS Graduate Program

11:30 ‐11:55 AM
“Photoactivation of targeted “nanodrugs” for the eradication of Staphylococcus aureus biofilms”
Daniel Meeker, Former SPaT Trainee, IBS Graduate Program

12:00 – 1:30 PM
Luncheon/Poster Viewing

1:30 – 2:30 PM
Keynote Presentation – Vishal Vaidya, PhD
Associate Professor of Medicine & Environmental Health
Harvard Medical School, Harvard T.H. Chan School of Public Health, Brigham and Women’s Hospital
“Systems and Translational Approach to Understand Toxicology”

2:30 – 3:00 PM
Closing Remarks and Final Poster Viewing


Systems Pharmacology and Toxicology (SPaT) Second Annual Symposium

May 7, 2015
10:00 a.m. – 2:30 p.m.
IDW Building, 2nd Floor

The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its second annual symposium featuring presentations by the four 2014-2015 SPaT trainees, plus two previous trainees, poster presentations by students from PCOL, INTX and IBS programs, as well as graduate students of SPaT Training Faculty, and a keynote presentation by Gary Petlz MD, Ph.D. (Stanford University).

9:00—10:00AM
Registration and Poster Set Up

10:00—10:15AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Trainin gGrant

10:15–10:35AM
“Design and Testing of Long Acting Viral Mediated Anti-METH Immunotherapies”
Chuck Hay, SPaT Trainee, Interdisciplinary Toxicology Graduate Program

10:35—10:55AM
Diversity Outbred Mice May Improve Preclinical Screening for Drug-Induced Liver Injury”
Lascelles Lyn-cook, SPaT Trainee, IBS Graduate Program

10:55 ‐11:15 AM
“A Tiny Solution to a Huge Problem: Employing Antibiotic-Loaded Gold Nanocages to Kill Staphylococcus aureus”
Daniel Meeker, SPaT Trainee, IBS Graduate Program

11:15 ‐11:35 AM
“ROS Signaling Differentially Regulates Bone Turnover in an Age-Specific Manner in Female Mice”
Alex Alund, SPaT Trainee, IBS Graduate Program

11:35 ‐11:55 AM
“Targeting Oxidants in an Infant Model of Sepsis-Induced Cardiorenal Syndrome”
Clark Sims, Past SPaT Trainee, Pharmacology Graduate Program

11:55 ‐12:15 AM
“Understanding the Role of Invasive Patterns and Stromal Response in the Development of Aggressive Vulvar Squamous Cell Carcinoma”
Emily Coffman Holthoff, Past SPaT Trainee,IBS Graduate Program

12:15 – 1:30 PM
Luncheon/Poster Viewing

1:30–2:30 PM
KeynotePresentation
Computational Genetics and Translational Discovery”
Gary Peltz, M.D., Ph.D., Professor of Anesthesiology
Perioperative and Pain Medicine, Stanford University

 2:00 – 2:30 PM
Closing Remarks and Final Poster Viewing

SPaT program 2015


Systems Pharmacology and Toxicology (SPaT)  First Annual Symposium

May 12, 2014
10:00 a.m. – 2:30 p.m.
IDW Building, 2nd Floor

 The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its first annual symposium featuring presentations by the three 2013-2014 SPaT trainees, poster presentations by students from PCOL, INTX and IBS programs, as well as graduate students of SPaT Training Faculty, and a keynote presentation by Edward Sherwood MD, Ph.D. (Vanderbilt University).

Group at PharmToxic-symposium-SPAT

Program Agenda

9:00 – 10:00 AM
Registration and Poster Set Up

10:00 – 10:15 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant

10:15 – 10:45 AM
“Targeting Renal Perfusion and Mitochondrial Oxidants in a Model of Infant Sepsis”
Clark Sims, SPaT Trainee, Pharmacology Graduate Program

10:45 – 11:15 AM
“Protection Against Ethanol-Induced Osteopenia in Female Mice by Dietary Antioxidants’
Alex Alund, SPaT Trainee, IBS Graduate Program

11:15 – 11:45 AM
“Perineural Invasion as an Indicator of Clinical Outcome in Vulvar Carcinoma”
Emily Coffman Holthoff, SPaT Trainee, IBS Graduate Program

11:45 AM – 1:00 PM
Luncheon and Poster Viewing

1:00 – 2:00 PM
Keynote Presentation: Edward Sherwood, M.D., Ph.D.
Professor of Anesthesiology, Vice Chair for Research, Vanderbilt University
“Augmentation of antimicrobial immunity by TLR4 agonists”

2:00 – 2:30 PM
Closing Remarks and Final Poster Viewing

SPaT Sherwood flyer