Recent Publications by our SPaT Trainees

Clemens MM, Vazquez JH, Kennon-McGill S, McCullough SS, James LP, McGill MR. Pre-treatment twice with liposomal clodronate protects against acetaminophen heptatotoxicity through a pre-conditioning effect.  Liver Res, in press.

Hay CE, Ewing LE, Hambuchen MD, Zintner SM, Small JC, Bolden CT, Fantegrossi WE, Margaritis P, Owens SM, Peterson, EC.  The development and characterization of an scFv-Fc fusion-based gene therapy to reduce the psychostimulant effects of methamphetamine abuse. J Pharmcol Exp Ther, jpet.119.261180, doi: 10.1124/jpet.119.261180, 2020

Aliyev, AT, LoBianco FV, Krager KJ, Aykin-Burns N. Assessment of cellular oxidation using a subcellular compartment-specific redox-sensitive green fluorescent protein. J. Vis Exp, 160, 2020.

Barnette D, Schlieff M, Flynn N, Payakachat S, Osborn L, Swamidass SJ, Miller GP. Dual mechanisms suppress meloxicam bioactiviation relative to sudoxicam. Toxicology, 440: 152478, 2020.

LoBianco FV, Krager K, Jahan SV, Carter G, Aykin-Burns N. The role of sirtuin 3 in radiation-indcued persistent liver injury.  Antioxidants, 9(5): 409, 2020.

Gaba RC, Elkhadragy L, Boas FE, Chaki S, Chen HH, El-Kebir M, Garcia KD, Giurini EF, Guzman G, LoBianco FV, Neto MJ, Newsom, JL, Qazi A, Regan M, Rund LA, Schwind RM, Stewart MC, Thomas FM, Whiteley HE, Wu J, Schook LB, Schachtschneider KM. Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation. Oncotarget, 160, 2020.

Skinner CM, Nookaew I, Ewing LE, Wongsurawat T, Jenjaroenpun P, Quick CM, Yee EU, Piccolo BD, Elsohly M, Walker LA, Gurley B, Koturbash I. Potential probiotic or trigger of gut inflammation – the Janus-faced nature of cannabinodial-rich cannabis extract. J. Diet Suppl, 1-18, 2020.

Miousse IR, Ewing LE, Skinner CM, Pathak R, Garg S, Kutanzi KR, Melnyk S, Hauer-Jensen M, Koturbash I. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. Am J Physiol Gastrointest Liver Physiol, 318(3): G439-G450, 2020.

Trentzch M, Nyamugenda E, Miles TK, Griffin H, Russell S, Koss B, Cooney KA, Phelan KD, Tackett AJ, Iyer S, Boysen G, Baldini G. Delivery of phoshatidylethanolamine blunts stress in heptoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum. Cell Death Discovery, 6:8, 2020.

Vazquez, JH, Clemens MM, Allard FD, Yee EU, Kennon-McGill, S, Mackintosh SG, Jaeschke H, Hambuchen M, McGill MR. Identification of serum biomarkers to distinguish hazardous and benign aminotransferase elevations. Toxicol Sci, 173(2): 244-254, 2020.

Hyatt WS, Hirsch CE, Russell LN, Chitre NM, Murname KS, Rice KC, Fantegrossi WE. The synthetic cathinone 3,4-methylenedioxypyrovalerone increases impulsive action in rats. Behav Pharmacol, 4: 309-321, 2020

McClenahan SJ, Kormos CM, Gunnell M, Hambuchen MD, Lamb P, Carroll FI, Lewin AH, Peterson EC, Owens SM. Design, synthesis and biological evaluation of a bi-specific vaccine against α-Pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats. Vaccine, 38(2): 336-344, 2019.

Griffin Ba, Caperton CO, Russell LN, Cabanlong CV, Wilson CD, Urquhart KR, Martins BS, Zita MD, Patton AL, Alund AW, Owens SM, Fantegrossi WE, Moran JH, Brents LK. In utero exposure to norbuprenorphine, a major metabolite of buprenorphine induces fetal opioid dependence and leads to neonatal opioid withdrawal syndrome. J Pharmacol Exp Ther, 370(1): 9-17, 2019.

MacLeod RS, Cawley KM, Gubrij I, Nookaew I, Onal M, OBrien CA. Effective CRISPR interference of an endogenous gene via a single transgene in mice. Sci Rep, 9(1): 17312, 2019.

Barnette, DA, Davis MA, Flynn N, Pidugu AS, Swamidass SJ, Miller GP. Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation. Biochem Pharmacol, 170: 113661, 2019.

Post GR, Yuan Y, Holthoff ER, Quick CM, Post SR. Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment. PLoS One, 14(11): e0224621, 2019

Hyatt WS, Berquist MD, Chitre NM, Russell LN, Rice KC, Murnane, KS, Fantegrossi WE. Repeated administration of synthetic cathinone 3,4-methylenedioxpyrovalerone persistently increases impulsive choice in rats. Behav Pharmacol, 2019.

McClenahan SJ, Hambuchen MD, Simecka CM, Gunnell MG, Berquist MD, Owens SM. Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley Rats. Drug Alcohol Depend, 195:140-147, 2019.

Ren Z, Ahn JH, Liu H, Tsai YH, Bhanu NV, Koss B, Allison DF, Ma A, Storey AJ, Wang P, Mackintosh SG, Edmondson RD, Groen RWJ, Martens AC, Garcia BA, Tackett AJ, Jin J, Cai L, Zheng D, Wang GG. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood 34(14), 1176-1189.

Chiang TC, Koss B, Su LJ, Washam CL, Byrum SD, Storey A, Tackett AJ. Effect of Sulforaphane and 5-Aza-2′-Deoxycytidine on Melanoma Cell Growth. Medicines (Basel), 6(3), 2019.

Shields BD, Koss B, Taylor EM, Storey AJ, West KL, Byrum SD, Mackintosh SG, Edmondson R, Mahmoud F, Shalin SC, Tackett AJ. Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer Res, 79(6):1113-1123, 2019.

Davis, M, Barnette D, Flynn N, Pidigu A, Swamidass SJ, Boysen G, Miller GP. CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches. Chem Res Toxicol, 32:1151-114, 2019.

Ewing LE, McGill MR, Yee EU, Quick CM, Skinner CM, Kennon-McGill S, Clemens M, Vazquez JH, McCullough SS, Williams DK, Kutanzi KR, Walker LA, ElSohly MA, James LP, Gurley BJ, Koturbash I. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules, 24(12):12, 2019.

Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules, 24(9):1694, 2019.

Tobacyk J, Parajuli N, Shrum S, Crow J, MacMillan-Crow LA. The first direct activity assay for the mitochondrial protease OMA1. Mitochondrion, 26;46:1-5, 2019.

Shrum S, Rusch NJ, MacMillan-Crow LA. Specific BK channel activator NS 11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury in vitro. Biomolecules, 9(12): 825, 2019.

Clemens MM, McGill MR, Udayan A. Mechanisms and biomarkers of liver regeneration after drug-induced liver injury. Adv Pharmacol 85: 241-262, 2019.

Kennon-McGill S, Clemens MM, McGill MR. Expression of drug metabolizing enzymes and transporters in cochlea: Implications for drug delivery and ototoxicity. Hearing Res, 379:98-102, 2019.

Clemens MM, Kennon-McGil S, Apte U, James LP, Finck BN, McGill MR. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3b and Wnt/b-catenin signaling. Food Chem Toxicol, 115:279-288, 2019.

Kurten RC, Rawson R, Shoda T, Duong LD, Adejumobi D, Levy R, Newbury RO, Rothenberg ME, Akuthota P, Wright BL, Dohil R, Jones SM, Aceves SS. Development and application of a functional human esophageal mucosa explant platform to eosinophilic esophagitis. Sci Rep, 9(1): 6206, 2019.

Meeker DG, Cooper KB, Renard RL, Mears SC, Smeltzer MS, Barnes CL. Comparative study of antibiotic elution profiles from alternative formulations of polymethylmethacrylate bone cement. J Arthroplasty, 34(7): 1458-1461, 2019.

Sarimollaoglu M, Stolarz AJ, Nedosekin DA, Garner BR, Fletcher TW, Galanzha EI, Rusch NJ, Zharov VP. High-speed microscopy for in vivo monitoring of lymph dynamics. J Biophotonics, 11(8): e201700126, 2018.

Lutkewitte, AJ, Schweitzer GG, Kennon-McGill S, Clemens MM, James LP, Jaeschke H, Finck, BN, McGill MR. Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration. Food Chem Toxicol, 115: 273-283, 2018.

Hay CE, Gonzalez 3rd, GA, Ewing LE, Reichard EE, Hambuchen MD, Nanaware-Kharade N, Alam S, Bolden CT, Owens SM, Margaritis P, Peterson, EC. Development and testing of AAV- delivered single-chain variable fragments for the treatment of methamphetamine abuse. PLoS One, 13(6): e0200060, 2018.

Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-Jensen M, Koturbash I. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol, 1-21, 2018.

Watt J, Alund AW, Pulliam CF, Mercer KE, Suva LJ, Chen JR, Ronis MJJ.  NOX4 deletion in male mice exacerbates the effect of ethanol on trabecular bone and osteoblastogeneis. J Pharmacol Exp Ther, 366(1): 46-57, 2018.

Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts, 8:83-92, 2017.

Sims CR, Singh SP, Mu S, Gokden N, Zakaria D, Nguyen TC, Mayeux, PR. Rolipram improves outcome in a rat model of infant sepsis-induced cardiorenal syndrome. Front Pharmacol, 8:237, 2017.

Alund AW, Mercer KE, Pulliam CF, Suva LJ, Chen JR, Badger TM, Ronis MJ. Partial protection by dietary antioxidants against ethanol-induced osteopenia and changes in bone morphology in female mice. Alcohol Clin Exp Res, 41(1): 46-56, 2017.

Parajuli N, Shrum S, Tobacyk J, Harb A, Arthur JM, MacMillan-Crow LA. Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLoS One, 12(10): e0185542, 2017.

Rom JS, Atwood DN, Beenken KE, Meeker DG, Loughran AJ, Spencer HJ, Lantz TL, Smeltzer MS. Impact of staphylococcus aureus regulatory mutations that modulate biofilm formation in the USA300 strain LAC on virulence in a murine bacteremia model. Virulence, 8(8): 1776-1790, 2017.

Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL. In vitro and in vivo characterization of the alkaloid nuciferine. PLoS One, 11:e0150602, 2016.

Shrum S, MacMillan-Crow LA, Parajuli N. Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. J Kidney, 2(1). pii:114, 2016.

Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, Spencer HJ, Smeltzer MS. XerC contributes to diverse forms of Staphylococcus aureus infection via agr-dependent and agr-independent pathways. Infect Immun, 84:1214-25, 2016.

Atwood DN, Beenken KE, Lantz TL, Meeker DG, Lynn WB, Mills WB, Spencer HJ, Smeltzer MS. Regulatory mutations impacting antibiotic susceptibility in an established Staphylococcus aureus biofilm. Antimicrob Agents Chemother, 60:1826-9, 2016.

Meeker DG, Jenkins SV, Miller EK, Beenken KE, Loughran AJ, Powless A, Muldoon TJ, Galanzha EI, Zharov VP, Smeltzer MS, Chen J. Synergistic photothermal and antibiotic killing of biofilm-associated Staphylococcus aureus using targeted antibiotic-loaded gold nanoconstructs. ACS Infectious Diseases, Epub 2016.

Meeker DG, Beenken KE, Mills WB, Loughran AJ, Spencer HJ, Lynn WB, Smeltzer MS. Evaluation of antibiotics active against methicillin-resistant Staphylococcus aureus based on activity in an established biofilm. Antimicrob Agents Chemother, 60(10): 5688-94, 2016.

Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and phenol-soluble modulins in the pathogenesis of osteomyelitis in diverse clinical isolates of Staphylococcus aureus. Infect Immun, 84(9):2586-94, 2016.

Jennings JA, Beenken KE, Skinner RA, Meeker DG, Smeltzer MS, Haggard WO, Troxel KS. 2016. Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World J Orthop, 7(8):467-74, 2016.

Meeker DG, Chen J, Smeltzer MS. Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond), 11:2379-82, 2016.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen JR, Badger TM, Van Remmen H, Ronis MJ. Reactive oxygen species differentially regulate bone turnover in an age-specific manner in catalase transgenic female mice. J Pharmacol Exp Ther, Epub 2016.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen J-R, Badger TM, Ronis MJ. Protections by Dietary Antioxidants Against Ethanol-Induced Osteopenia and Changes in Bone Morphology in Female Mice. Alcoholism: Clin Exp Res, 2016, in press.

Sims CR, Nguyen TC, Mayeux PR. Could Biomarkers Direct Therapy for the Septic Patient? J Pharmacol Exp Ther, 357:228-39. 2016.

Holthoff E, Spencer H, Kelly T, Post SR, Quick, CM. Pathologic features of aggressive vulvar squamous cell carcinoma are associated with an epithelial-mesenchymal transition. Hum Pathol,  56:22-30, 2016.

Mazur A, Holthoff ER, Vadali S, Kelly T, Post SR. Cleavage of type I collagen by fibroblast activation protein- enhances class A scavenger receptor mediated macrophage adhesion. PLoS One, e0150287, 2016.

Holthoff ER, Jeffus SK, Gehlot A, Stone R, Erickson SW, Kelly T, Quick CM, Post SR. Perineural invasion is an independent pathologic indicator of recurrence in vulvar squamous cell carcinoma. Am J Surg Pathol, 39:1070-4, 2015.

Jeffus SK, Gehlot A, Holthoff ER, Stone R, Spencer H, Kelly T, Post SR, Quick CM. A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. Am J Surg Pathol, 39:1226-33, 2015.

Tai S, Hyatt WS, Gu C, Franks LN, Vasiljevik T, Brents LK, Prather PL, Fantegrossi WE. Repeated administration of phytocannabinoid delta(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner. Pharmacol Res, 102:22-32, 2015.

Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, Gupta RK, Lee CY, Beenken KE, Smeltzer MS. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen, 4:436-51, 2015.

Wang Z, Sims CR, Patil NK, Gokden N, Mayeux PR. Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther, 352(1):61-6, 2015.

Marshell R, Kearney-Ramos T, Brents LK, Hyatt WS, Tai S, Prather, PL, Fantegrossi WE. In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid delta-9 THC in mice: inhalation versus intraperitoneal injection. Pharmacol Biochem Behav, 124:40-47, 2014.

Yang CS, Mercer KE, Alund AW, Suva LJ, Badger TM, Ronis MJ. Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Exp Biol Med, 239:1380-9 2014.

Delta-9-THC exposure attenuates aversive effects and reveals appetitive effects of K2/’Spice’ constituent JWH-018 in mice. Hyatt WS, Fantegrossi WE. Behav Pharmacol, 24:253-257, 2014.

Sims CR, MacMillan-Crow LA, Mayeux PR. Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis. Clin Pharmacol Ther, 96:662-4, 2014.

Singh M, Odeniyi (Adejumobi now) DT, Apostolov, EO, Savenka A, Fite, T, Wangila GW, Walker RB, Basnakian AG. Protective effect of zinc-n-acetylcysteine on rat kidney during cold storage. Am J Physiol Renal Physiol, 305:F1022-F1030, 2013.