Recent Publications by our SPaT Trainees

Hyatt WS, Berquist MD, Chitre NM, Russell LN, Rice KC, Murnane, KS, Fantegrossi WE. Repeated administration of synthetic cathinone 3,4-methylenedioxpyrovalerone persistently increases impulsive choice in rats. Behav Pharmacol, 2019.

McClenahan SJ, Hambuchen MD, Simecka CM, Gunnell MG, Berquist MD, Owens SM. Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley Rats. Drug Alcohol Depend 195:140-147, 2019.

Chiang TC, Koss B, Su LJ, Washam CL, Byrum SD, Storey A, Tackett AJ. Effect of Sulforaphane and 5-Aza-2′-Deoxycytidine on Melanoma Cell Growth. Medicines (Basel) 6(3), 2019.

Shields BD, Koss B, Taylor EM, Storey AJ, West KL, Byrum SD, Mackintosh SG, Edmondson R, Mahmoud F, Shalin SC, Tackett AJ. Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer Res 79(6):1113-1123, 2019.

Davis, M, Barnette D, Flynn N, Pidigu A, Swamidass SJ, Boysen G, Miller GP. CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches. Chem Res Toxicol 32:1151-114, 2019.

Ewing LE, McGill MR, Yee EU, Quick CM, Skinner CM, Kennon-McGill S, Clemens M, Vazquez JH, McCullough SS, Williams DK, Kutanzi KR, Walker LA, ElSohly MA, James LP, Gurley BJ, Koturbash I. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules 24(12):12, 2019.

Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules 24(9):1694, 2019.

Tobacyk J, Parajuli N, Shrum S, Crow J, MacMillan-Crow LA. The first direct activity assay for the mitochondrial protease OMA1. Mitochondrion. 26;46:1-5, 2019.

Kennon-McGill S, Clemens MM, McGill MR. Expression of drug metabolizing enzymes and transporters in cochlea: Implications for drug delivery and ototoxicity. Hearing Res 379:98-102, 2019.

Clemens MM, Kennon-McGil S, Apte U, James LP, Finck BN, McGill MR. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3b and Wnt/b-catenin signaling. Food Chem Toxicol 115:279-288, 2019.

Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-Jensen M, Koturbash I. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol 1-21, 2018.

Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts. 8:83-92, 2017.

Sims CR, Singh SP, Mu S, Gokden N, Zakaria D, Nguyen TC, Mayeux, PR. Rolipram improves outcome in a rat model of infant sepsis-induced cardiorenal syndrome. Front Pharmacol. 8:237, 2017.

Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL. In vitro and in vivo characterization of the alkaloid nuciferine. PLoS One. 11:e0150602, 2016.

Shrum S, MacMillan-Crow LA, Parajuli N. Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. J Kidney. 2(1). pii:114, 2016.

Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, Spencer HJ, Smeltzer MS. XerC contributes to diverse forms of Staphylococcus aureus infection via agr-dependent and agr-independent pathways. Infect Immun. 84:1214-25, 2016.

Atwood DN, Beenken KE, Lantz TL, Meeker DG, Lynn WB, Mills WB, Spencer HJ, Smeltzer MS. Regulatory mutations impacting antibiotic susceptibility in an established Staphylococcus aureus biofilm. Antimicrob Agents Chemother. 60:1826-9, 2016.

Meeker DG, Jenkins SV, Miller EK, Beenken KE, Loughran AJ, Powless A, Muldoon TJ, Galanzha EI, Zharov VP, Smeltzer MS, Chen J. Synergistic photothermal and antibiotic killing of biofilm-associated Staphylococcus aureus using targeted antibiotic-loaded gold nanoconstructs. ACS Infectious Diseases. Epub 2016.

Meeker DG, Beenken KE, Mills WB, Loughran AJ, Spencer HJ, Lynn WB, Smeltzer MS. Evaluation of antibiotics active against methicillin-resistant Staphylococcus aureus based on activity in an established biofilm. Antimicrob Agents Chemother. 60(10): 5688-94, 2016.

Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and phenol-soluble modulins in the pathogenesis of osteomyelitis in diverse clinical isolates of Staphylococcus aureus. Infect Immun. 84(9):2586-94, 2016.

Jennings JA, Beenken KE, Skinner RA, Meeker DG, Smeltzer MS, Haggard WO, Troxel KS. 2016. Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World J Orthop. 7(8):467-74, 2016.

Meeker DG, Chen J, Smeltzer MS. Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond). 11:2379-82, 2016.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen JR, Badger TM, Van Remmen H, Ronis MJ. Reactive oxygen species differentially regulate bone turnover in an age-specific manner in catalase transgenic female mice. J Pharmacol Exp Ther. Epub 2016.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen J-R, Badger TM, Ronis MJ. Protections by Dietary Antioxidants Against Ethanol-Induced Osteopenia and Changes in Bone Morphology in Female Mice. Alcoholism: Clin Exp Res. 2016, in press.

Sims CR, Nguyen TC, Mayeux PR. Could Biomarkers Direct Therapy for the Septic Patient? J Pharmacol Exp Ther. 357:228-39. 2016.

Holthoff E, Spencer H, Kelly T, Post SR, Quick, CM. Pathologic features of aggressive vulvar squamous cell carcinoma are associated with an epithelial-mesenchymal transition. Hum Pathol.  56:22-30, 2016.

Mazur A, Holthoff ER, Vadali S, Kelly T, Post SR. Cleavage of type I collagen by fibroblast activation protein- enhances class A scavenger receptor mediated macrophage adhesion. PLoS One. e0150287, 2016.

Holthoff ER, Jeffus SK, Gehlot A, Stone R, Erickson SW, Kelly T, Quick CM, Post SR. Perineural invasion is an independent pathologic indicator of recurrence in vulvar squamous cell carcinoma. Am J Surg Pathol. 39:1070-4, 2015.

Jeffus SK, Gehlot A, Holthoff ER, Stone R, Spencer H, Kelly T, Post SR, Quick CM. A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. Am J Surg Pathol. 39:1226-33, 2015.

Tai S, Hyatt WS, Gu C, Franks LN, Vasiljevik T, Brents LK, Prather PL, Fantegrossi WE. Repeated administration of phytocannabinoid delta(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner. Pharmacol Res. 102:22-32, 2015.

Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, Gupta RK, Lee CY, Beenken KE, Smeltzer MS. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen. 4:436-51, 2015.

Wang Z, Sims CR, Patil NK, Gokden N, Mayeux PR. Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther. 352(1):61-6, 2015.

Marshell R, Kearney-Ramos T, Brents LK, Hyatt WS, Tai S, Prather, PL, Fantegrossi WE. In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid delta-9 THC in mice: inhalation versus intraperitoneal injection. Pharmacol Biochem Behav. 124:40-47, 2014.

Yang CS, Mercer KE, Alund AW, Suva LJ, Badger TM, Ronis MJ. Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Exp Biol Med. 239:1380-9 2014.

Delta-9-THC exposure attenuates aversive effects and reveals appetitive effects of K2/’Spice’ constituent JWH-018 in mice. Hyatt WS, Fantegrossi WE. Behav Pharmacol. 24:253-257, 2014.

Sims CR, MacMillan-Crow LA, Mayeux PR. Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis. Clin Pharmacol Ther. 96:662-4, 2014.

Singh M, Odeniyi (Adejumobi now) DT, Apostolov, EO, Savenka A, Fite, T, Wangila GW, Walker RB, Basnakian AG. Protective effect of zinc-n-acetylcysteine on rat kidney during cold storage. Am J Physiol Renal Physiol. 305:F1022-F1030, 2013.