Recent Publications by our SPaT Trainees

Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts. 8:83-92, 2017.

Singh M, Odeniyi (Adejumobi now) DT, Apostolov, EO, Savenka A, Fite, T, Wangila GW, Walker RB, Basnakian AG. Protective effect of zinc-n-acetylcysteine on rat kidney during cold storage. Am J Physiol Renal Physiol. 305:F1022-F1030, 2013.

Shrum S, MacMillan-Crow LA, Parajuli N. Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. J Kidney. 2(1). pii:114, 2016.


Marshell R, Kearney-Ramos T, Brents LK, Hyatt WS, Tai S, Prather, PL, Fantegrossi WE. In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid delta-9 THC in mice: inhalation versus intraperitoneal injection. Pharmacol Biochem Behav. 124:40-47, 2014.

Delta-9-THC exposure attenuates aversive effects and reveals appetitive effects of K2/’Spice’ constituent JWH-018 in mice. Hyatt WS, Fantegrossi WE. Behav Pharmacol. 24:253-257, 2014.

Tai S, Hyatt WS, Gu C, Franks LN, Vasiljevik T, Brents LK, Prather PL, Fantegrossi WE. Repeated administration of phytocannabinoid delta(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner. Pharmacol Res. 102:22-32, 2015.

Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL. In vitro and in vivo characterization of the alkaloid nuciferine. PLoS One. 11:e0150602, 2016.

Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, Gupta RK, Lee CY, Beenken KE, Smeltzer MS. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen. 4:436-51, 2015.

Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, Spencer HJ, Smeltzer MS. XerC contributes to diverse forms of Staphylococcus aureus infection via agr-dependent and agr-independent pathways. Infect Immun. 84:1214-25, 2016.

Atwood DN, Beenken KE, Lantz TL, Meeker DG, Lynn WB, Mills WB, Spencer HJ, Smeltzer MS. Regulatory mutations impacting antibiotic susceptibility in an established Staphylococcus aureus biofilm. Antimicrob Agents Chemother. 60:1826-9, 2016.

Meeker DG, Jenkins SV, Miller EK, Beenken KE, Loughran AJ, Powless A, Muldoon TJ, Galanzha EI, Zharov VP, Smeltzer MS, Chen J. Synergistic photothermal and antibiotic killing of biofilm-associated Staphylococcus aureus using targeted antibiotic-loaded gold nanoconstructs. ACS Infectious Diseases. Epub 2016.

Meeker DG, Beenken KE, Mills WB, Loughran AJ, Spencer HJ, Lynn WB, Smeltzer MS. Evaluation of antibiotics active against methicillin-resistant Staphylococcus aureus based on activity in an established biofilm. Antimicrob Agents Chemother. 60(10): 5688-94, 2016.

Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and phenol-soluble modulins in the pathogenesis of osteomyelitis in diverse clinical isolates of Staphylococcus aureus. Infect Immun. 84(9):2586-94, 2016.

Jennings JA, Beenken KE, Skinner RA, Meeker DG, Smeltzer MS, Haggard WO, Troxel KS. 2016. Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World J Orthop. 7(8):467-74, 2016.

Meeker DG, Chen J, Smeltzer MS. Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond). 11:2379-82, 2016.

Yang CS, Mercer KE, Alund AW, Suva LJ, Badger TM, Ronis MJ. Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Exp Biol Med. 239:1380-9 2014.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen JR, Badger TM, Van Remmen H, Ronis MJ. Reactive oxygen species differentially regulate bone turnover in an age-specific manner in catalase transgenic female mice. J Pharmacol Exp Ther. Epub 2016.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen J-R, Badger TM, Ronis MJ. Protections by Dietary Antioxidants Against Ethanol-Induced Osteopenia and Changes in Bone Morphology in Female Mice. Alcoholism: Clin Exp Res. 2016, in press.

Sims CR, MacMillan-Crow LA, Mayeux PR. Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis. Clin Pharmacol Ther. 96:662-4, 2014.

Wang Z, Sims CR, Patil NK, Gokden N, Mayeux PR. Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther. 352(1):61-6, 2015.

Sims CR, Nguyen TC, Mayeux PR. Could Biomarkers Direct Therapy for the Septic Patient? J Pharmacol Exp Ther. 357:228-39. 2016.

Sims CR, Singh SP, Mu S, Gokden N, Zakaria D, Nguyen TC, Mayeux, PR. Rolipram improves outcome in a rat model of infant sepsis-induced cardiorenal syndrome. Front Pharmacol. 8:237, 2017.

Holthoff E, Spencer H, Kelly T, Post SR, Quick, CM. Pathologic features of aggressive vulvar squamous cell carcinoma are associated with an epithelial-mesenchymal transition. Hum Pathol.  56:22-30, 2016.

Holthoff ER, Jeffus SK, Gehlot A, Stone R, Erickson SW, Kelly T, Quick CM, Post SR. Perineural invasion is an independent pathologic indicator of recurrence in vulvar squamous cell carcinoma. Am J Surg Pathol. 39:1070-4, 2015.

Jeffus SK, Gehlot A, Holthoff ER, Stone R, Spencer H, Kelly T, Post SR, Quick CM. A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. Am J Surg Pathol. 39:1226-33, 2015.

Mazur A, Holthoff ER, Vadali S, Kelly T, Post SR. Cleavage of type I collagen by fibroblast activation protein- enhances class A scavenger receptor mediated macrophage adhesion. PLoS One. e0150287, 2016.